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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Blood Lymphocyte and Neutrophil Response of Cultured Rainbow Trout, Oncorhynchus mykiss, Administered Varying Dosages of an Oral Medicinal Mushroom-Based Immunomodulator—"Fin-ImmuneTM"

Volume 12, Edição 2, 2010, pp. 185-192
DOI: 10.1615/IntJMedMushr.v12.i2.90
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RESUMO

In a 10-week (May−August 2008) Phase I trial, 840 1+-year-old rainbow trout, Oncorhynchus mykiss, received a commercial oral immunomodulator, Fin-ImmuneTM, at four different dosages (0, 10, 20, and 30 mg/g−1) to evaluate immune response and growth. The overall objective was to determine an optimal dosage of this product for rainbow trout that provides enhanced immunity with maximal growth and health. Biweekly blood samples were taken from 10 randomly selected fish in each tank (30 samples per treatment) to evaluate the duration of enhanced immunity conferred by Fin-ImmuneTM. The immunological assessment included serum white blood cell (lymphocyte and neutrophil) densities and blood hematocrit (packed cell volume %). Of these three variables, only lymphocyte density increased significantly among trout fed Fin-ImmuneTM at 20 and 30 mg/g−1, which peaked at week 6. At week 7, all trout were switched to regular feed (lacking Fin-ImmuneTM), and by week 10, lymphocyte levels decreased among all levels but were still greater than at week 0. There was growth impairment at the highest dose of Fin-ImmuneTM tested (30 mg/g−1), which can be associated with a physiological compensatory mechanism due to a dose-specific threshold level. Thus, our main objective of this Phase I study was achieved: the 20 mg/g−1 dose of Fin-ImmuneTM should be the most efficacious (of those we tested) to use for a Phase II disease-challenge trial.

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