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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i4.90
pages 415-421

Preliminary Results on Antigenotoxic Effects of Dried Mycelia of Two Medicinal Mushrooms in Drosophila melanogaster Somatic Mutation and Recombination Test

Aygul Kylyc
Arts and Science Faculty, Department of Biology, Inonu University, Malatya, Turkey
Elif Yesilada
Arts and Science Faculty, Department of Biology, Inonu University, Malatya, Turkey

RESUMO

In this study, the antigenotoxic effects of dried mycelia from Trametes versicolor and Pleurotus ostreatus were investigated using a Drosophila melanogaster somatic mutation and recombination test (SMART), which is based on the principle that the loss of heterozygosity of suitable recessive marker hairs, such as multiple wing (mwh) and flare-3 (flr3), can lead to the formation of mutant clones of larval cells, which then are expressed as spots on the wings of the adult flies. In this study, dried mycelia from T. versicolor and P. ostreatus alone (7.5, 15, and 30 mg) were examined for genotoxicity and combined with mitomycin C (MMC; 0.05 mM) for antigenotoxicity. Commonly known mutagen which is mitomycin C (MMC) was used as positive control. The results showed that the dried mycelia of mushrooms were not genotoxic themselves. Nevertheless, the mushrooms have antigenotoxic activity by reducing the frequency of MMC-induced spots in varying proportions. Thus, powders of these 2 fungi were able to suppress somatic cell mutation induced by MMC. These results suggest that T. versicolor and P. ostreatus have antigenotoxic activity, including antirecombinogenic activity.


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