Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i2.10
pages 101-107

Characterization of Blood (β-1,3-glucan and Anti-(β-glucan Antibody in Hemodialysis Patients Using Culinary-Medicinal Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae)

Ken-Ichi Ishibashi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Masaharu Yoshida
Renal Unit of the Department of Internal Medicine, Hachiouji Medical Center of Tokyo Medical University, Hachioji, Tokyo
Iwao Nakabayashi
Renal Unit of the Department of Internal Medicine, Hachiouji Medical Center of Tokyo Medical University, Hachioji, Tokyo
Noriko Yoshikawa
Renal Unit of the Department of Internal Medicine, Hachiouji Medical Center of Tokyo Medical University, Hachioji, Tokyo
Noriko N. Miura
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Naohito Ohno
Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

RESUMO

β-glucan is a major component of fungal cell walls and shows various immunopharmacological activities including antitumor activity. Previously, we detected anti-β-glucan antibody in human sera. Anti-β-glucan antibody participates in the immune response to fungal cell wall β-glucan. Patients on dialysis are at high risk of infection including fungal infections. We examined the plasma β-glucan level and the titer of anti-β-glucan antibody in dialysis patients. We measured plasma β-1,3-glucan concentrations with the limulus G test and anti-β-glucan antibody titers by ELISA with Candida β-glucan-coated plates. We also examined the influence of the period of dialysis and the kind of dialysis membrane. The patients were positive for β-1,3-glucan in their plasma. The anti-β-glucan antibody titer was lower in the dialysis patients than in healthy volunteers. Long-term dialysis patients showed lower anti-β-glucan antibody titers than short-term dialysis patients. No significant difference was found between the kinds of dialysis membrane. The titer of anti-β-glucan antibody as recognition molecule of β-glucan was low in dialysis patients compared with healthy volunteers. This is likely to be one factor explaining the sensitivity to infection of the dialysis patients. An appropriate application of culinary-medicinal mushroom such as Agaricus brasiliensis has potential for the prevention of fungal infection in dialysis patients.


Articles with similar content:

Anti-β-Glucan Antibody in Bovine Sera
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 4
Yoshiyuki Adachi, Noriko N. Miura, Tsunenori Iriki, Yu-ichiro Kurone, Naohito Ohno, Ken-Ichi Ishibashi, Chikaku Dogasaki, Masuro Motoi
Effect of Oral Administration of Dried Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae), Fruit Bodies on Anti-β-Glucan Antibody Titers in Humans
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 2
Yoshiyuki Adachi, Noriko N. Miura, Ying Liu, Naohito Ohno, Ken-Ichi Ishibashi, Masuro Motoi
Analysis of the Titer and Reactivity of Antibody/ies Against Fungal Cell Wall β-Glucans in Human Sera
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 2
Mayu Morita, Yoshiyuki Adachi, Noriko N. Miura, Ying Liu, Naohito Ohno, Ken-Ichi Ishibashi, Masuro Motoi
Anti β-Glucan Antibody in Cancer Patients (Preliminary Report)
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 1
Yoshiyuki Adachi, Osamu Mizukami, Noriko N. Miura, Naohito Ohno, Ken-Ichi Ishibashi, Masuro Motoi
β-Glucan of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Cooperatively Induces Tumor Necrosis Factor-α and Interleukin-6 with Lipopolysaccharide by Binding to Dectin-1
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Mi Jeong Kim, Ha Won Kim, Se Young Choung, Dong Hee Lee, Byong Kak Kim, Su Kyoung Sung