RESUMO

Diabetes mellitus (DM) is a common endocrine and metabolic disease caused by protein and fat metabolism disorders as the main clinical manifestation due to the relative or absolute deficiency of insulin secretion in the body. Despite significant prevention and treatment efforts, the number of people with DM is still increasing. A safe and effective resource to prevent and treat DM is urgently needed. In recent years, many reports have indicated that medicinal mushrooms have a hypoglycemic effect. Among them, Coprinus comatus has great potential for development as a hypoglycemic drug or food; it is an emerging medicinal and edible fungus with a variety of nutrients (polysaccharides, unsaturated fatty acids, dietary fibers, vitamins, trace elements, amino acids, etc.). These ingredients have been closely linked to the hypoglycemic effects of C. comatus, possibly by increasing insulin release, protecting islet cells from invasion, enhancing antioxidant activity, regulating metabolic pathways, and reducing inflammation. This review preliminarily summarizes the hypoglycemic effect of C. comatus by introducing the ingredients it contains, which can provide theoretical support for the development of C. comatus as a potential hypoglycemic resource.