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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v16.i5.90
pages 499-506

Modulatory Effect of Crude Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes), on Hematological and Antioxidant Indices in Plasmodium berghei−infected Mice

Olarewaju M. Oluba
Department of Chemical Sciences, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria; Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria
Kayode E. Adebisi
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria; Department of Biochemistry, College of Pure & Applied Sciences, Kwara State University, Malete, Kwara State, Nigeria
George O. Eidangbe
Department of Medical Biochemistry, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
Adewale A. Odutuga
Department of Chemical Sciences, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria
E. Chukwu Onyeneke
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin-City, Nigeria

RESUMO

Hematological and antioxidant effects of the aqueous extract of fruiting bodies of Ganoderma lucidum were evaluated in Plasmodium berghei−infected mice. Extract was administered at doses of 100, 250, and 500 mg/kg body weight by an intragastric tube once daily for 14 d starting from the fourth day after parasite inoculation. At the end of treatment period, mice in each group were sacrificed and blood was collected for hematological and biochemical analyses. A significant (P<0.05) decrease was observed in serum malondialdehyde content with a corresponding significant (P<0.05) increase in superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glucose 6-phosphate dehydrogenase activities in the extract-treated groups compared to the infected but untreated group. The results obtained suggest that crude aqueous extract of G. lucidum fruiting bodies possesses potent antioxidant activity that protects hemoglobin against Plasmodium-induced oxidative damage. These findings seem to justify the use of the plant in traditional African and Chinese medicine as an anti-inflammatory and antimicrobial agent.


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