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ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
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Medicinal Properties of Coprinoid Mushrooms (Basidiomycetes, Agaricales)
RESUMO
Myco-pharmacological investigations of bioactive metabolites and medicinal properties of mushrooms play an important role in the development of new biotech products and biopharmaceuticals. Concerning physiological activities and medicinal properties, Coprinoid mushrooms are poorly studied and not at all exploited. The majority of these organisms are fimicolous. However, many of them have also been found on trees and decaying wood (Navarro-Gonzalez et al., in preparation). Based on molecular data, the traditional genus Coprinus Pers. has now been divided into four clades: Coprinus, Coprinopsis, Coprinellus, and Parasola (Redhead et al., 2001). For simplicity, we use the traditional nomenclature.
Important in view of biological safety, Coprini are generally nonpathogenic to humans or animals. Less than 10 cases of opportunistic mycoses by Coprini have been recorded worldwide. About 30 years ago, mycelia were isolated from two hearts of immunosuppressed patients who had undergone heart surgery and, in more recent times, from the lungs of three patients suffering from leukemia, known as non-Hodgkin’s lymphoma, who received intensive cytotoxic treatment. Recently, a strain has also been isolated from human skin lesions (Kues et al., 2003). Coprinus comatus,/i> (O.F.Mull.) S.F.Gray may aggravate eczematous skin lesions and induce delayed-type allergic reactions by spores in individuals with atopic dermatitis. Intense efforts have been invested to identify clinically relevant allergens. C. comatus rCop c1, a protein of no known function, was able to induce strong specific skin reactions in sensitized individuals (Helbling et al., 2002).
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Banks Alice M., Barker Gary L. A., Bailey Andy M., Foster Gary D., Draft Genome Sequence of the Coprinoid Mushroom Coprinopsis strossmayeri , Genome Announcements, 5, 14, 2017. Crossref