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International Journal of Physiology and Pathophysiology

Publicou 4 edições por ano

ISSN Imprimir: 2155-014X

ISSN On-line: 2155-0158

SJR: 0.116

Body's Response to Dosed Hypoxic Hypoxia in Healthy Subjects and Patients with Pre-Diabetic Disorders of Hydrogen Metabolism

Volume 8, Edição 1, 2017, pp. 45-55
DOI: 10.1615/IntJPhysPathophys.v8.i1.50
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RESUMO

The aim of the study was to find out the features of body's response to acute hypoxic test in patients with pre-diabetic disorders of carbohydrate metabolism. The study involved 22 healthy subjects and 18 patients with pre-diabetic disorders of hydrogen metabolism, aged 50 to 74 years. Each of them underwent dosed hypoxic test (breathing gas mixture containing 12% oxygen for up to 20 minutes) with monitoring of blood saturation (SpO2), respiratory rate, blood pressure, heart rate, and a standard glucose tolerance test (GTT) to check the concentration of blood plasma glucose and insulin. The patients with pre-diabetic hydrogen metabolism disturbances revealed a significant decrease in SpO2 and less effective functioning of the respiratory and the cardiovascular systems compared with the healthy subjects without impaired hydrogen metabolism. After redistribution of examined subjects into a subgroup with satisfactory resistance to hypoxia (subgroup 1, SpO2 more than 80%) and with low resistance to hypoxia (subgroup 2, SpO2 80% or less) depending on the degree of hypoxia-induced SpO2 decrease, we have found that the fasting glucose level after 2-hour GTT was significantly higher in a subgroup 2 compared to a subgroup 1. The results obtained indicate the relationship of the body's response to hypoxia, including the degree of arterial hypoxemia in acute hypoxic test and the level of fasting glucose at a standard GTT. The patients with pre-diabetic disturbances of carbohydrate metabolism are characterized with lower resistance to hypoxic hypoxia.

CITADO POR
  1. Khalangot Mykolay, Gurianov Vitaliy, Vaiserman Alexander, Strele Ieva, Fedash Vasile, Kravchenko Victor, Diabetes in Eastern Europe, in Diabetes Mellitus in Developing Countries and Underserved Communities, 2017. Crossref

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