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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i2.30
pages 109-116

Thymosin β4: A Potential Molecular Target for Tumor Therapy

Yongtao Xiao
Shanghai Institute of Pediatric Research, Shanghai, China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,China
Yingwei Chen
Department of Gastroenterology, Shanghai Jiao Tong University, School of Medicine, Xin Hua Hospital, Shanghai, China;Shanghai Institute of Pediatric Research, Shanghai, China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition
Jie Wen
Shanghai Institute of Pediatric Research, Shanghai, China
Weihui Yan
Shanghai Institute of Pediatric Research, Shanghai, China
Kejun Zhou
Shanghai Institute of Pediatric Research, Shanghai, China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,China
Wei Cai
Shanghai Institute of Pediatric Research, Shanghai, China ; Department of Pediatric Surgery, Shanghai Jiao Tong University, School of Medicine, Xin Hua Hospital, Shanghai, China

RESUMO

Thymosin β4 (Tβ4), a 5 kDa protein, has been demonstrated to play an important role in a variety of biological activities, such as actin sequestering, cellular motility, migration, inflammation, and damage repair. Recently, several novel findings provided compelling evidence that Tβ4 played a key role in facilitating tumor metastasis and angiogenesis. It has been found that Tβ4 expressed increasingly in a number of metastatic tumors, which was associated with an increased expression of a known angiogenic factor, vascular endothelial growth factor. Thus, Tβ4 provided a potential target of opportunity for cancer management, especially for cancer metastasis therapy.