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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i1.10
pages 1-15

DLK1-MEG3 Imprinted Domain MicroRNAs in Cancer Biology

Leonidas Benetatos
Transfusion Unit, General Hospital of Preveza, Preveza, Greece
Evangelos Voulgaris
Department of Medical Oncology, University Hospital of loannina, loannina, Greece
George Vartholomatos
Molecular Biology Laboratory, University Hospital of loannina, loannina, Greece

RESUMO

A rapidly growing body of evidence highlights the involvement of DLK1-MEG3 imprinted domain in cell biology and cancer pathogenesis. The imprinted domain contains protein-coding genes, long non-coding RNAs, and various small non-coding RNAs. The imprinted microRNAs located here interact with important transcription factors, modulate fundamental signaling cascades, form molecular signatures with diagnostic and prognostic potential, and could differentiate chemoresistant from chemosensitive disease. Moreover, as they can be detected in patients' serum, are easy to obtain, and can be used as adjuvant diagnostic biomarkers with the potential of monitoring disease progression and response to treatment.