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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.2013006641
pages 93-101

ANP-NPRA Signaling Pathway−A Potential Therapeutic Target for the Treatment of Malignancy

Zhilong Zhao
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Jia Zhang
Department of Thoracic Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Min Li
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Ya Yang
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Kai Sun
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Jiansheng Wang
Tianjin University

RESUMO

It was well established that the atrial natriuretic peptide (ANP)/natriuretic peptide receptor-A (NPRA) signaling pathway controls natriuretic, diuretic, vasorelaxant, and anti-proliferative responses in the regulation of the human cardiovascular system by previous studies. Yet in recent years, more and more evidence has shown that the ANP/NPRA signaling pathway plays an important role in human cancer. For example, NPRA is abundantly expressed on tumorigenic mouse and human prostate cancer (PCa) cells, but not in nontumorigenic prostate epithelial cells and down-regulation of NPRA-induced apoptosis in PCa cells. Dexamethasone can increase the expression of ANP markedly, and that is the reason why dexamethasone is the cornerstone in the treatment of multiple myeloma. NPRA deficiency can substantially protect C57BL/6 mice from lung, skin, and ovarian cancers. These results strongly suggest ANP and NPRA may play an anti-cancer and carcinogenesis role, respectively, and this signaling pathway could be a more potent target for cancer therapy. In light of these new insights, this review will summarize the structures, functions, and their regulation by cell signaling, and their different impacts on tumors.

Palavras-chave: ANP, NPRA, cancer, target, treatment

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