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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Histone Deacetylase Co-Repressor Complex Control of Runx2 and Bone Formation

Volume 17, Edição 3, 2007, pp. 187-196
DOI: 10.1615/CritRevEukarGeneExpr.v17.i3.20
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RESUMO

A decade has passed since the transcription factor, Runx2, was found to be essential for osteoblast development and chondrocyte hypertrophy. During the last 10 years, our understanding of Runx2's physiological roles and the molecular mechanisms whereby it regulates gene expression to control cell-cycle progression and cellular differentiation has increased exponentially. Runx2 is expressed in osteoblasts, prehypertrophic chondrocytes, mesenchymal cells of the perichondrium, T lymphocytes, endothelial cells, and breast and prostate epithelial cells, with increased expression observed in breast and prostate carcinomas. Although Runx2 and other mammalian Runt domain proteins were originally described as transcriptional activators, they are also transcriptional repressors and thus maintain functional similarities with their Drosophila homolog, Runt. Runx2 binds a consensus DNA sequence but does not possess any enzymatic activities that directly affect chromatin structure. It alters gene expression by recruiting cofactors to gene regulatory elements. Histone deacetylases (HDACs) are among the co-repressors that interact with Runx2. In this review, we summarize data demonstrating that several HDACs and their associated proteins interact with Runx2, regulate its activity, and affect bone formation. HDACs are components of multiprotein complexes that interact with many transcription factors and are subject to regulation by extracellular signals. The elucidation of HDAC complex components that influence Runx2 activity in specific cell types and in response to various extracellular stimuli will increase our understanding of how this crucial transcription factor functions, and how we might be able to control its activity to influence bone formation or reduce bone disease associated with cancer metastasis.

CITADO POR
  1. Park Eun-Sil, Park Jiyeon, Franceschi Renny T., Jo Misung, The role for runt related transcription factor 2 (RUNX2) as a transcriptional repressor in luteinizing granulosa cells, Molecular and Cellular Endocrinology, 362, 1-2, 2012. Crossref

  2. Lian Jane B., Gravallese Ellen M., Stein Gary S., Osteoblasts and their Signaling Pathways, in Osteoimmunology, 2011. Crossref

  3. Wuelling Manuela, Pasdziernik Markus, Moll Carina N, Thiesen Andrea M, Schneider Sabine, Johannes Christian, Vortkamp Andrea, The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis, Cell Cycle, 12, 14, 2013. Crossref

  4. Chu Tianqing, Teng Jiajun, Jiang Liyan, Zhong Hua, Han Baohui, Lung cancer-derived Dickkopf1 is associated with bone metastasis and the mechanism involves the inhibition of osteoblast differentiation, Biochemical and Biophysical Research Communications, 443, 3, 2014. Crossref

  5. Sinha Krishna M., Zhou Xin, Genetic and molecular control of osterix in skeletal formation, Journal of Cellular Biochemistry, 114, 5, 2013. Crossref

  6. McGee-Lawrence Meghan E., McCleary-Wheeler Angela L., Secreto Frank J., Razidlo David F., Zhang Minzhi, Stensgard Bridget A., Li Xiaodong, Stein Gary S., Lian Jane B., Westendorf Jennifer J., Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts, Bone, 48, 5, 2011. Crossref

  7. Franceschi Renny T., Ge Chunxi, Wilson Christopher G., Osteoblasts of Craniofacial Bone, in Mineralized Tissues in Oral and Craniofacial Science, 2013. Crossref

  8. Sinha Krishna M, Yasuda Hideyo, Zhou Xin, deCrombrugghe Benoit, Osterix and NO66 Histone Demethylase Control the Chromatin of Osterix Target Genes During Osteoblast Differentiation, Journal of Bone and Mineral Research, 29, 4, 2014. Crossref

  9. Wuelling Manuela, Vortkamp Andrea, Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification, Pediatric Nephrology, 25, 4, 2010. Crossref

  10. Xu Yue, Hammerick Kyle E., James Aaron W., Carre Antoine L., Leucht Philipp, Giaccia Amato J., Longaker Michael T., Inhibition of Histone Deacetylase Activity in Reduced Oxygen Environment Enhances the Osteogenesis of Mouse Adipose-Derived Stromal Cells, Tissue Engineering Part A, 15, 12, 2009. Crossref

  11. Adhami Mitra D, Rashid Harunur, Chen Haiyan, Clarke John C, Yang Yang, Javed Amjad, Loss of Runx2 in Committed Osteoblasts Impairs Postnatal Skeletogenesis, Journal of Bone and Mineral Research, 30, 1, 2015. Crossref

  12. Jensen Eric D., Gopalakrishnan Rajaram, Westendorf Jennifer J., Regulation of gene expression in osteoblasts, BioFactors, 2010. Crossref

  13. Montecino Martin, Stein Gary, Stein Janet, Zaidi Kaleem, Aguilar Rodrigo, Multiple levels of epigenetic control for bone biology and pathology, Bone, 81, 2015. Crossref

  14. Zhang Zhongli, Deepak Vishwa, Meng Lingyi, Wang Linghui, Li Yushan, Jiang Qing, Zeng Xianlu, Liu Wenguang, Analysis of HDAC1-mediated regulation of Runx2-induced osteopontin gene expression in C3h10t1/2 cells, Biotechnology Letters, 34, 2, 2012. Crossref

  15. Varela Nelson, Aranguiz Alejandra, Lizama Carlos, Sepulveda Hugo, Antonelli Marcelo, Thaler Roman, Moreno Ricardo D., Montecino Martin, Stein Gary S., van Wijnen Andre J., Galindo Mario, Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells, Journal of Cellular Physiology, 231, 5, 2016. Crossref

  16. Hong Jiyong, Luesch Hendrik, Largazole: From discovery to broad-spectrum therapy, Natural Product Reports, 29, 4, 2012. Crossref

  17. Stemig Melissa, Astelford Kristina, Emery Ann, Cho Jangyeun J., Allen Ben, Huang Tsang-hai, Gopalakrishnan Rajaram, Mansky Kim C., Jensen Eric D., Tuukkanen Juha, Deletion of Histone Deacetylase 7 in Osteoclasts Decreases Bone Mass in Mice by Interactions with MITF, PLOS ONE, 10, 4, 2015. Crossref

  18. Meng Xianzhong, Ao Lihua, Song Yong, Babu Ashok, Yang Xiaoping, Wang Maorong, Weyant Michael J., Dinarello Charles A., Cleveland Joseph C., Fullerton David A., Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis, American Journal of Physiology-Cell Physiology, 294, 1, 2008. Crossref

  19. Zainabadi Kayvan, Liu Cassie J., Guarente Leonard, Kim Jung-Eun, SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2, PLOS ONE, 12, 5, 2017. Crossref

  20. Bae Han-Sol, Yoon Won-Joon, Cho Young-Dan, Islam Rabia, Shin Hye-Rim, Kim Bong-Soo, Lim Jin-Muk, Seo Min-Seok, Cho Seo-Ae, Choi Kang-Young, Baek Seung-Hak, Kim Hong-Gee, Woo Kyung-Mi, Baek Jeong-Hwa, Lee Yun-Sil, Ryoo Hyun-Mo, An HDAC Inhibitor, Entinostat/MS-275, Partially Prevents Delayed Cranial Suture Closure in Heterozygous Runx2 Null Mice, Journal of Bone and Mineral Research, 32, 5, 2017. Crossref

  21. Souza Alann T.P., Bezerra Barbara L.S., Oliveira Fabiola S., Freitas Gileade P., Bighetti Trevisan Rayana L., Oliveira Paulo T., Rosa Adalberto L., Beloti Marcio M., Effect of bone morphogenetic protein 9 on osteoblast differentiation of cells grown on titanium with nanotopography, Journal of Cellular Biochemistry, 119, 10, 2018. Crossref

  22. Duncan Henry F., Yamauchi Yukako, Current and Future Views on Pulp Exposure Management and Epigenetic Influences, in Clinical Approaches in Endodontic Regeneration, 2019. Crossref

  23. Liu Hongliang, Zhao Hongmou, Lin Hua, Li Zhong, Xue Hanzhong, Zhang Yunzhi, Lu Jun, Relationship of COL9A1 and SOX9 Genes with Genetic Susceptibility of Postmenopausal Osteoporosis, Calcified Tissue International, 106, 3, 2020. Crossref

  24. Bab Itai A., Sela Jona J., Cellular and Molecular Aspects of Bone Repair, in Principles of Bone Regeneration, 2012. Crossref

  25. Shreya S., Malavika D., Priya V. Raj, Selvamurugan N., Regulation of Histone Deacetylases by MicroRNAs in Bone, Current Protein & Peptide Science, 20, 4, 2019. Crossref

  26. Nakamichi Ryo, Kurimoto Ryota, Tabata Yusuke, Asahara Hirosi, Transcriptional, epigenetic and microRNA regulation of growth plate, Bone, 137, 2020. Crossref

  27. Ali Sayed A., Dobson Jason R., Lian Jane B., Stein Janet L., van Wijnen Andre J., Zaidi Sayyed K., Stein Gary S., A Runx2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation, Journal of Cell Science, 2012. Crossref

  28. Galea Gabriel L., Paradise Christopher R., Meakin Lee B., Camilleri Emily T., Taipaleenmaki Hanna, Stein Gary S., Lanyon Lance E., Price Joanna S., van Wijnen Andre J., Dudakovic Amel, Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2, Gene, 763, 2020. Crossref

  29. Lee Su-Ui, Kwak Han Bok, Pi Sung-Hee, You Hyung-Keun, Byeon Seong Rim, Ying Yongcheng, Luesch Hendrik, Hong Jiyong, Kim Seong Hwan, In Vitro and In Vivo Osteogenic Activity of Largazole, ACS Medicinal Chemistry Letters, 2, 3, 2011. Crossref

  30. Ge Wenshu, Shi Lei, Zhou Yongsheng, Liu Yunsong, Ma Gui‐e, Jiang Yong, Xu Yongwei, Zhang Xiao, Feng Hailan, Inhibition of Osteogenic Differentiation of Human Adipose‐Derived Stromal Cells by Retinoblastoma Binding Protein 2 Repression of RUNX2‐Activated Transcription, STEM CELLS, 29, 7, 2011. Crossref

  31. Zainabadi Kayvan, The variable role of SIRT1 in the maintenance and differentiation of mesenchymal stem cells, Regenerative Medicine, 13, 3, 2018. Crossref

  32. Meyer Mark B., Benkusky Nancy A., Lee Chang-Hun, Pike J.Wesley, Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 during Osteoblast-lineage Cell Differentiation, Journal of Biological Chemistry, 289, 28, 2014. Crossref

  33. Chen Zhi, Zhang Zhiwei, Guo Li, Wei Xiaochun, Zhang Yang, Wang Xiaojian, Wei Lei, The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development, Bone & Joint Research, 9, 2, 2020. Crossref

  34. Ge Wenshu, Liu Yunsong, Chen Tong, Zhang Xiao, Lv Longwei, Jin Chanyuan, Jiang Yong, Shi Lei, Zhou Yongsheng, The epigenetic promotion of osteogenic differentiation of human adipose-derived stem cells by the genetic and chemical blockade of histone demethylase LSD1, Biomaterials, 35, 23, 2014. Crossref

  35. Ali Syed A., Zaidi Sayyed K., Dobson Jason R., Shakoori Abdul R., Lian Jane B., Stein Janet L., van Wijnen Andre J., Stein Gary S., Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes, Proceedings of the National Academy of Sciences, 107, 9, 2010. Crossref

  36. Pratap Jitesh, Akech Jacqueline, Wixted John J., Szabo Gabriela, Hussain Sadiq, McGee-Lawrence Meghan E., Li Xiaodong, Bedard Krystin, Dhillon Robinder J., van Wijnen Andre J., Stein Janet L., Stein Gary S., Westendorf Jennifer J., Lian Jane B., The Histone Deacetylase Inhibitor, Vorinostat, Reduces Tumor Growth at the Metastatic Bone Site and Associated Osteolysis, but Promotes Normal Bone Loss, Molecular Cancer Therapeutics, 9, 12, 2010. Crossref

  37. Jing Dian, Hao Jin, Shen Yu, Tang Ge, Li Mei-Le, Huang Shi-Hu, Zhao Zhi-He, The role of microRNAs in bone remodeling, International Journal of Oral Science, 7, 3, 2015. Crossref

  38. Lian Jane B., Stein Gary S., Montecino Martin, Stein Janet L., van Wijnen Andre J., Genetic and Epigenetic Control of the Regulatory Machinery for Skeletal Development and Bone Formation: Contributions of Vitamin D3, in Vitamin D, 2011. Crossref

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