Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 2.156 FI de cinco anos: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Volumes:
Volume 30, 2020 Volume 29, 2019 Volume 28, 2018 Volume 27, 2017 Volume 26, 2016 Volume 25, 2015 Volume 24, 2014 Volume 23, 2013 Volume 22, 2012 Volume 21, 2011 Volume 20, 2010 Volume 19, 2009 Volume 18, 2008 Volume 17, 2007 Volume 16, 2006 Volume 15, 2005 Volume 14, 2004 Volume 13, 2003 Volume 12, 2002 Volume 11, 2001 Volume 10, 2000 Volume 9, 1999 Volume 8, 1998 Volume 7, 1997 Volume 6, 1996 Volume 5, 1995 Volume 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v17.i4.10
pages 259-269

The Phosphoinositide-Phospholipase C (PI-PLC) Pathway in the Mouse Oocyte

Brigitte Lefevre
INSERM U566/CEA/DRR/LGAG/Univ Paris 7, Batiment 05, route du Panorama, F-92260, Fontenay-aux-roses, France
Arlette Pesty
INSERM U566/CEA/DRR/LGAG/Univ Paris 7, Batiment 05, route du Panorama, F-92260, Fontenay-aux-roses, France
Anne-Marie Courtot
INSERM U566/CEA/DRR/LGAG/Univ Paris 7, Batiment 05, route du Panorama, F-92260, Fontenay-aux-roses, France
Catarina Vaz Carreto Martins
INSERM U566/CEA/DRR/LGAG/Univ Paris 7, Batiment 05, route du Panorama, F-92260, Fontenay-aux-roses, France
Ophelie Broca
La Pitié Salpêtrière, UF Biologie de la Reproduction, Paris, France
Anne Denys
INSERM Eri-18, Univ Paris 13, Bobigny, France
Emilie Arnault
INSERM U566/CEA/DRR/LGAG/Univ Paris 7, Batiment 05, route du Panorama, F-92260, Fontenay-aux-roses, France
Catherine Poirot
La Pitié Salpêtrière, UF Biologie de la Reproduction, Paris, France
Nathalie Avazeri
Société Bracer-Biotech, INRA, Jouy-en-Josas, France

RESUMO

As highlighted in this review, the phosphoinositide-phospholipase C pathway is strongly implicated in the control of mouse oocyte meiosis. The pathway becomes progressively functional as oocyte growth advances, and it appears to play a role in the G2/M transition when meiosis resumes, at least in the in vitro spontaneous model. Even if the inositol 1,4,5-trisphosphate receptors are present from the beginning, they function and release Ca2+ when the follicular antrum appears. Phospholipase C β1 (PLCβ1) is first exclusively localized to the nucleus and then migrates to the cytoplasm when the oocyte is fully grown. During oocyte maturation PLCβ1 is active in the cytoplasm before it migrates and becomes active in the nucleus just prior to germinal vesicle breakdown. Because a similar circuit is observed for protein kinase C α (PKCα), PKCβ1, PKCβ2, and active mitogen-activated protein kinase, it is tempting to envisage that a feedback loop occurs between these pathways as demonstrated in other cell types. The chronology of these molecular movements into the oocyte reveals the particular and important role of the nucleus phosphoinositide cycle during oocyte meiosis. It appears also that this chronology is crucial and that defects leading to an inappropriate intracellular localization can have dramatic consequences. Such anomalies can prevent the production of competent oocytes and lead to fertility problems.


Articles with similar content:

Signaling Pathways Involved in Glucocorticoid-Induced Apoptosis of Thymocytes
Critical Reviews™ in Immunology, Vol.25, 2005, issue 4
Francoise Giraud, Jean-Claude Sulpice, Sandrine Lepine
Molecular Aspects of Cannabinoid Receptors
Critical Reviews™ in Neurobiology, Vol.11, 1997, issue 2-3
Lisa A. Matsuda
The Granule Pathway of Programmed Cell Death
Critical Reviews™ in Immunology, Vol.25, 2005, issue 3
Philip G. Ashton-Rickardt
GABAergic Cortical Neuron Chromatin as a Putative Target to Treat Schizophrenia Vulnerability
Critical Reviews™ in Neurobiology, Vol.15, 2003, issue 2
Alessandro Guidotti, Dennis R. Grayson, Colin P. Mitchell, Marin Veldic, Lucio Tremolizzo, Erminio Costa
Ca2+/Calmodulin Signaling in NMDA-lnduced Synaptic Plasticity
Critical Reviews™ in Neurobiology, Vol.14, 2000, issue 2
Margaret E. Gnegy