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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 2.156 FI de cinco anos: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v17.i4.60
pages 335-346

Parameters of Quantitative Trait Loci

Jian Yan
Department of Orthopedics Surgery, Campbell Clinic, and Department of Pathology, University of Tennessee Health Science Center, Memphis, TN
Weikuan Gu
Department of Orthopedics Surgery, Campbell Clinic, and Department of Pathology, University of Tennessee Health Science Center, Memphis, TN

RESUMO

Most traits of medical relevance follow quantitative inheritance patterns. The genetic dissection of quantitative traits poses special challenges for geneticists mainly because of low penetrance and gene-gene and gene-environment interactions. Emerging genome resources and technologies are enabling systematic investigation of the genetic architecture of quantitative traits in more efficient ways. This article summarizes the current state of medical quantitative trait locus (QTL) mapping—escribing the methods, limitations, and achievements in the detection and characterization of QTLs.


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