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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Interrelationships between Radiation-Induced Mutations and Modifications in Gene Expression Linked to Cancer

Volume 8, Edição 3-4, 1998, pp. 257-276
DOI: 10.1615/CritRevEukarGeneExpr.v8.i3-4.20
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RESUMO

Ionizing radiation induces cancer in humans, but the mechanisms are not established. One simple way by which radiation could induce cancer is by inducing a genetic mutation in one or more of the multiple steps in the oncogenic pathway. However, many investigators favor the hypothesis that a mutator phenotype is necessary for a single cell to acquire the multiple genetic changes found in cancer. The alternative idea that ionizing radiation might induce an epigenetic heritable mutator phenotype has gained momentum in the last decade or so. A number of laboratories have observed a phenomenon termed 'delayed reproductive death', which is manifested as a reduced cloning efficiency, and also increased frequencies of gene locus mutations or chromosome aberrations that persist for many generations after radiation exposure. It is theorized that these endpoints arise due to a long-lived alteration in gene expression induced by radiation. Ionizing radiation is well known to induce gene expression, as it triggers the p53 pathway, as well as a series of early response genes, including c-jun and egr-1. However, there is no model from the gene expression field that could account for an epigenetic mutator effect that persists for tens or even hundreds of generations.

CITADO POR
  1. Liang Li, Shao Changshun, Deng Li, Mendonca Marc S., Stambrook Peter J., Tischfield Jay A., Radiation-induced genetic instability in vivo depends on p53 status, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 502, 1-2, 2002. Crossref

  2. NAKAMURA Eizo, MAKISHIMA Akio, HAGINO Kyoko, OKABE Kazunori, Accumulation of radium in ferruginous protein bodies formed in lung tissue: association of resulting radiation hotspots with malignant mesothelioma and other malignancies, Proceedings of the Japan Academy, Series B, 85, 7, 2009. Crossref

  3. Rugo Rebecca E., Schiestl Robert H., Increases in Oxidative Stress in the Progeny of X-Irradiated Cells, Radiation Research, 162, 4, 2004. Crossref

  4. Huang Lei, Grim Suzanne, Smith Leslie E., Kim Perry M., Nickoloff Jac A., Goloubeva Olga G., Morgan William F., Ionizing Radiation Induces Delayed Hyperrecombination in Mammalian Cells, Molecular and Cellular Biology, 24, 11, 2004. Crossref

  5. Durant Stephen T., Paffett Kimberly S., Shrivastav Meena, Timmins Graham S., Morgan William F., Nickoloff Jac A., UV Radiation Induces Delayed Hyperrecombination Associated with Hypermutation in Human Cells, Molecular and Cellular Biology, 26, 16, 2006. Crossref

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