Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 2.156 FI de cinco anos: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Volume 30, 2020 Volume 29, 2019 Volume 28, 2018 Volume 27, 2017 Volume 26, 2016 Volume 25, 2015 Volume 24, 2014 Volume 23, 2013 Volume 22, 2012 Volume 21, 2011 Volume 20, 2010 Volume 19, 2009 Volume 18, 2008 Volume 17, 2007 Volume 16, 2006 Volume 15, 2005 Volume 14, 2004 Volume 13, 2003 Volume 12, 2002 Volume 11, 2001 Volume 10, 2000 Volume 9, 1999 Volume 8, 1998 Volume 7, 1997 Volume 6, 1996 Volume 5, 1995 Volume 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v6.i4.20
pages 345-375

Regulation and Repair of Double-Strand DNA Breaks

David T. Weaver
Division of Tumor Immunology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115 and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115


Double-strand break (DSB) repair in mammalian cells involves the DNA-dependent protein kinase (DNA-PK). DNA-PK is composed of three subunits, a catalytic kinase subunit (DNA-PKcs) mutated in the mouse scid complementation group and the Ku heterodimer. Ku-deficient and DNA-PKcs-deficient cell lines and an animal model have illuminated important features of the DSB repair pathway. Additional factors relevant to several essential functions of DNA replication may point to some overlap between DNA synthesis and DNA repair in eukaryotes. The DNA-PK complex may have broader functions based on its possible involvement in transcriptional regulation and cell cycle checkpoints.

Articles with similar content:

The c-erbB-2 Protein in Oncogenesis: Molecular Structure to Molecular Epidemiology
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 2-3
Walter P. Carney, Paul W. Brandt-Rauf, Matthew R. Pincus
Origin and Roles of Nuclear Matrix Proteins. Specific Functions of the MAR-Binding Protein MeCP2/ARBP
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 3-4
Wolf H. Stratling, Fang Yu
The Transcription Regulator Kruppel-Like Factor 4 and Its Dual Roles of Oncogene in Glioblastoma and Tumor Suppressor in Neuroblastoma
Onco Therapeutics, Vol.7, 2016, issue 1-2
Swapan K. Ray
The Cbl Family of Signal Transduction Molecules
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 4
Linda Smit , Jannie Borst
The Cbl Protooncogene Product: From an Enigmatic Oncogene to Center Stage of Signal Transduction
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 2-3
Patrice Douillard, Mark L. Lupher, Jr., Nancy L. Lill, Satoshi Ota, Christopher E. Andoniou, Hamid Band, Navin Rao, Sachiko Miyake