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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Association of IL-6 -597 G/A Polymorphism with Cancer Risk: Evidence from a Meta-Analysis

Volume 27, Edição 3, 2017, pp. 211-217
DOI: 10.1615/CritRevEukaryotGeneExpr.2017019372
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RESUMO

Although it has been suggested that the interleukin-6(IL-6) gene -597G/A polymorphism may be a risk factor for cancer, the conclusions from previous studies are inconsistent. To clarify the precise interrelation, we performed a comprehensive meta-analysis of 6 case-control studies involving 1,605 subjects (706 cases and 899 controls). The overall results showed no significant association between the IL6 -597G/A polymorphism and cancer risk in the overall population (CC vs GG: OR = 2.38, 95% CI = 0.62–9.14; CG vs GG: OR = 1.23, 95% CI = 0.66–2.27; dominant model: OR = 1.32, 95% CI = 0.63–2.79; recessive model: OR = 1.93, 95% CI = 0.72–v5.17). Subgroup analysis by ethnicity and cancer type yielded the same result. Therefore, the current evidence from this meta-analysis did not support the hypothesis of IL-6 -597G/A polymorphism as a risk factor of cancer. Conclusive evidence on the effects of this variant in cancer should be addressed in future studies.

CITADO POR
  1. Candido Saverio, Tomasello Barbara Maria Rita, Lavoro Alessandro, Falzone Luca, Gattuso Giuseppe, Libra Massimo, Novel Insights into Epigenetic Regulation of IL6 Pathway: In Silico Perspective on Inflammation and Cancer Relationship, International Journal of Molecular Sciences, 22, 18, 2021. Crossref

  2. Zhou Linghui, Zheng Yi, Tian Tian, Liu Kang, Wang Meng, Lin Shuai, Deng Yujiao, Dai Cong, Xu Peng, Hao Qian, Kang Huafeng, Dai Zhijun, Associations of interleukin-6 gene polymorphisms with cancer risk: Evidence based on 49,408 cancer cases and 61,790 controls, Gene, 670, 2018. Crossref

  3. Harun-Or-Roshid Md., Ali Md. Borqat, Jesmin , Mollah Md. Nurul Haque, Chen Zhongxue, Statistical meta-analysis to investigate the association between the Interleukin-6 (IL-6) gene polymorphisms and cancer risk, PLOS ONE, 16, 3, 2021. Crossref

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