Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
Association of IL-6 -597 G/A Polymorphism with Cancer Risk: Evidence from a Meta-Analysis
RESUMO
Although it has been suggested that the interleukin-6(IL-6) gene -597G/A polymorphism may be a risk factor for cancer, the conclusions from previous studies are inconsistent. To clarify the precise interrelation, we performed a comprehensive meta-analysis of 6 case-control studies involving 1,605 subjects (706 cases and 899 controls). The overall results showed no significant association between the IL6 -597G/A polymorphism and cancer risk in the overall population (CC vs GG: OR = 2.38, 95% CI = 0.62–9.14; CG vs GG: OR = 1.23, 95% CI = 0.66–2.27; dominant model: OR = 1.32, 95% CI = 0.63–2.79; recessive model: OR = 1.93, 95% CI = 0.72–v5.17). Subgroup analysis by ethnicity and cancer type yielded the same result. Therefore, the current evidence from this meta-analysis did not support the hypothesis of IL-6 -597G/A polymorphism as a risk factor of cancer. Conclusive evidence on the effects of this variant in cancer should be addressed in future studies.
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Zhou Linghui, Zheng Yi, Tian Tian, Liu Kang, Wang Meng, Lin Shuai, Deng Yujiao, Dai Cong, Xu Peng, Hao Qian, Kang Huafeng, Dai Zhijun, Associations of interleukin-6 gene polymorphisms with cancer risk: Evidence based on 49,408 cancer cases and 61,790 controls, Gene, 670, 2018. Crossref
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Harun-Or-Roshid Md., Ali Md. Borqat, Jesmin , Mollah Md. Nurul Haque, Chen Zhongxue, Statistical meta-analysis to investigate the association between the Interleukin-6 (IL-6) gene polymorphisms and cancer risk, PLOS ONE, 16, 3, 2021. Crossref