Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 2.156 FI de cinco anos: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Volume 30, 2020 Volume 29, 2019 Volume 28, 2018 Volume 27, 2017 Volume 26, 2016 Volume 25, 2015 Volume 24, 2014 Volume 23, 2013 Volume 22, 2012 Volume 21, 2011 Volume 20, 2010 Volume 19, 2009 Volume 18, 2008 Volume 17, 2007 Volume 16, 2006 Volume 15, 2005 Volume 14, 2004 Volume 13, 2003 Volume 12, 2002 Volume 11, 2001 Volume 10, 2000 Volume 9, 1999 Volume 8, 1998 Volume 7, 1997 Volume 6, 1996 Volume 5, 1995 Volume 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v19.i2.40
pages 139-169

Coordinated Regulation of Ras-, Rac-, and Ca2+-Dependent Signaling Pathways

Hans H. Grunicke
Medical University of Innsbruck, Biocenter, Division of Medical Biochemistry, Austria


Stimulation of cells by a broad variety of agonists results in a coordinated activation of Ca2+-, Ras-, and Rac-dependent pathways, which have to synergize to yield the corresponding biological response. This synergy requires a dense net of mutually positive and negative regulatory mechanisms. These include Ca2+-mediated activation of guanine nucleotide exchange proteins, resulting in increased levels of GTP-charged Ras and/or Rac or inactivation of small GTPases by Ca2+-mediated activation of GTPase-activating enzymes. Likewise, Ras as well as Rac control regulatory mechanisms, resulting in increased or diminished levels of cytosolic-free Ca2+. The biochemical mechanisms underlying these effects are discussed, with special reference to regulation of Ca2+ signaling by Ras and Rac.

Articles with similar content:

Regulation of Thymocyte Survival by Transcriptional Coactivators
Critical Reviews™ in Immunology, Vol.26, 2006, issue 6
Zuoming Sun, Zhaofeng Huang, Huimin Xie, Ruiqing Wang
Signals for Activation of the GM-CSF Promoter and Enhancer in T Cells
Critical Reviews™ in Immunology, Vol.17, 1997, issue 3-4
M. Frances Shannon, M. A. Vadas, P. N. Cockerill, L. S Coles
Role and Modulation of G Protein-Coupled Receptor Signaling in Inflammatory Processes
Critical Reviews™ in Immunology, Vol.22, 2002, issue 2
Maria Stella Lombardi, Annemieke Kavelaars, Cobi J. Heijnen
Proteolytic Cleavage of Molecules Involved in Cell Death or Survival Pathways: A Role in the Control of Apoptosis?
Critical Reviews™ in Eukaryotic Gene Expression, Vol.11, 2001, issue 4
Martin J. S. Dyer, Loraine Karran
Developmental Aspects of NMDA Receptor Function
Critical Reviews™ in Neurobiology, Vol.12, 1998, issue 3
Mary Lou Vallano