Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v18.i1.10
pages 1-9

Determinants of Pathologic Mineralization

Thorsten Kirsch
Musculoskeletal Research Laboratories, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA

RESUMO

Physiologic mineralization is necessary for the formation of skeletal tissues and for their appropriate functions during adulthood. Mineralization has to be controlled and restricted to specific regions. If the mineralization process occurs in regions that normally do not mineralize, there can be severe consequences (pathologic or ectopic mineralization). Recent findings have indicated that physiologic and pathologic mineralization events are initiated by matrix vesicles, membrane-enclosed particles released from the plasma membranes of mineralization-competent cells. The understanding of how these vesicles are released from the plasma membrane and initiate the mineralization process may provide novel therapeutic strategies to prevent pathologic mineralization. In addition, other regulators (activators and inhibitors) of physiologic mineralization have been identified and characterized, and there is evidence that the same factors also contribute to the regulation of pathologic mineralization. Finally, programmed cell death (apoptosis) may be a contributor to physiologic mineralization and if occurring after tissue injury may induce pathologic mineralization and mineralization-related differentiation events in the injured and surrounding areas. This review describes how the understanding of mechanisms and factors regulating physiologic mineralization can be used to develop new therapeutic strategies to prevent pathologic or ectopic mineralization events.


Articles with similar content:

Apoptosis in Membranous Bone Formation: Role of Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 1
Pierre J. Marie, Dominique Modrowski, Olivia Fromigue
Long-Term Effects of Chromatin Remodeling and DNA Damage in Stem Cells Induced by Environmental and Dietary Agents
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 4
C. Greer Vestal, Christine Richardson, Bhawana Bariar
Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks
Critical Reviews™ in Immunology, Vol.35, 2015, issue 5
Shawn P. Fahl, Yong Zhang, Anne-Cecile E. Duc, David L. Wiest, Minshi Wang
Shigellosis: Innate Mechanisms of Inflammatory Destruction of the Intestinal Epithelium, Adaptive Immune Response, and Vaccine Development
Critical Reviews™ in Immunology, Vol.23, 2003, issue 5-6
P. J. Sansonetti, Armelle Phalipon
Regulation of Mast Cell Responses in Health and Disease
Critical Reviews™ in Immunology, Vol.31, 2011, issue 6
Michael A. Beaven, Alasdair M. Gilfillan