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Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v18.i1.20
pages 11-33

Progesterone Receptor Isoform Functions in Normal Breast Development and Breast Cancer

Anastasia Kariagina
Department of Physiology, Breast Cancer and the Environment Research Center, Michigan State University, East Lansing, MI 48824, USA
Mark D. Aupperlee
Department of Physiology, Breast Cancer and the Environment Research Center, and Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA
Sandra Z. Haslam
Department of Physiology, Breast Cancer and the Environment Research Center, and Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA

RESUMO

Progesterone acting through two isoforms of the progesterone receptor (PR), PRA and PRB, regulates proliferation and differentiation in the normal mammary gland in mouse, rat, and human. Progesterone and PR have also been implicated in the etiology and pathogenesis of human breast cancer. The focus of this review is recent advances in understanding the role of the PR isoform—specific functions in the normal breast and in breast cancer. Also discussed is information obtained from rodent studies and their relevance to our understanding of the role of progestins in breast cancer etiology.