Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v16.i2.40
pages 155-170

Cellular Genetics of Host Susceptibility and Resistance to Virus Infection

Donald H. Rubin
Research Medicine, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212; Department of Medicine, Division of Infectious Diseases; and Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232
H. Earl Ruley
Vanderbilt University School of Medicine


Viruses are obligate intracellular parasites that rely upon the host cell for activities essential to their life cycles. Gene-trap mutagenesis provides a rapid, genome-wide strategy to identify candidate cellular genes required for virus replication. The candidate genes provide a starting point for mechanistic studies of cellular processes that participate in the virus life cycle and may provide targets for novel antiviral therapies.

Articles with similar content:

Elimination of Virus-Specific Cytotoxic T Cells in the Liver
Critical Reviews™ in Immunology, Vol.22, 2002, issue 1
Gunther Dennert
Oncogene- and Tumor-Suppressor Gene-Related Proteins in Plants and Fungi
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Peter Loidl, Adele Loidl
Pharmacogenomics and Its Potential Impact on Drug and Formulation Development
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.22, 2005, issue 5
Diane J. Burgess, Karin Regnstrom
Replication of Damaged Genomes
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 4
Alden C. Klarer, W. Glenn McGregor
Genetically Engineered Natural Killer Cells as a Means for Adoptive Tumor Immunotherapy
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Susanne Michen , Achim Temme