Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v16.i2.30
pages 143-154

Control of Tooth Morphogenesis by Runx2

Hyun-Mo Ryoo
Department of Cell and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea
Xiu-Ping Wang
Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA

RESUMO

Odontogenesis is a complex process in which the interplay of signaling cascades of the epithelium and mesenchyme is critical. Evidence for the involvement of Runx2−a well-known osteogenic master transcription factor−in odontogenesis, has been accumulating. Haploinsufficiency of Runx2 in humans results in cleido-cranial dysplasia (CCD), characterized by supernumerary teeth; in Runx2−/− mice, molar odontogenesis does not proceed beyond the late bud stage. In this article, we discuss the role of Runx2 in tooth development, specifically in the signaling interplay of the epithelium and mesenchyme during the transition from bud stage to cap stage. Runx2 is an important molecule of the dental mesenchyme; its expression is induced by epithelial fibroblast growth factor (FGF), and it is involved in regulating the induction of mesenchymal signaling back to the dental epithelium for epithelial morphogenesis. In addition, we discuss the role of the two major isoforms of Runx2, and other Runx family genes, in odontogenic processes.


Articles with similar content:

The Role of Nitric Oxide and Cyclooxygenase-2 in Attenuating Apoptosis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 2
Andreas von Knethen, Bernhard Brune
Braf Mutations Are Associated With High Levels of Phosphorylated RKIP in Melanoma Cell Lines: Potential Prognostic Significance
Forum on Immunopathological Diseases and Therapeutics, Vol.2, 2011, issue 2
S. Ekmekcioglu, Sara Huerta-Yepez, C. M. Rivera-Pazos, Elizabeth A. Grimm, Mario I. Vega, G. Antonio-Andres, G. Baay-Guzman
Role of Runx Proteins in Chondrogenesis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Carolina A. Yoshida, Toshihisa Komori
Regulation of RUNX1 Transcriptional Function by GATA-1
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 4
Kamaleldin E. Elagib, Adam N. Goldfarb
Structure and Function of the Immune Semaphorin CD100/SEMA4D
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Abdellah Elhabazi, Armand Bensussan, Laurence Boumsell, Isabelle Chabbert-de Ponnat, Anne Marie-Cardine