Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v14.i3.10
24 pages

Structure and Function of Histone Methyltransferases

Raymond C. Trievel
University of Michigan Medical School, Department of Biological Chemistry, Ann Arbor, MI 48109-0606

RESUMO

Histones are the major protein constituent of chromatin in the eukaryotic nucleus. These proteins undergo a host of different post-translational modifications, including phosphorylation, acetylation, and methy-lation, which have profound effects on the remodeling of chromatin. Histone modifications can function either individually or combinatorially to govern such processes as transcription, replication, DNA repair, and apoptosis. Recent studies have focused on histone arginine and lysine methylation and the roles of these modifications in transcriptional regulation and the establishment of heterochromatin. Concomitantly, several families of histone methyltransferases (HMTs) have been identified that catalyze the methylation of specific arginines or lysines in histones H3 and H4. Not surprisingly, many of these methyltransferase genes had been previously identified as important genetic regulators in organisms such as yeast and Drosophila, which underscores the importance of histone methylation in transcriptional control and chromatin remodeling. Structures of several representatives of these HMT families have recently been determined, yielding insight into their catalytic mechanism and histone substrate specificity. The focus of this review is to briefly summarize the roles of histone methylation in chromatin remodeling and to discuss the structures, substrate specificities, and mechanisms of the different classes of HMTs.


Articles with similar content:

Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Mark L. Johnson, Douglas T. Summerfield
Deacetylation of Chromatin and Gene Expression Regulation: A New Target for Epigenetic Therapy
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 1-2
Heidi Olzscha, Nicholas B. La Thangue, Semira Sheikh
Extracellular Vesicles as Potential Mediators of Epigenetic Reprogramming
Forum on Immunopathological Diseases and Therapeutics, Vol.6, 2015, issue 3-4
Anna Lewandowska Ronnegren
Transcription Regulator Yin-Yang 1: From Silence to Cancer
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 3-4
Weidong Zhu, Hermes Garban, Samuel Y. Olson
Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML Factors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 1&2
Sayyed Kaleem Zaidi, Janet L. Stein, Jane B. Lian, Martin Montecino, Andre J. van Wijnen, Amjad Javed, Gary S. Stein, Christopher Lengner