Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 2.156 FI de cinco anos: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Volumes:
Volume 30, 2020 Volume 29, 2019 Volume 28, 2018 Volume 27, 2017 Volume 26, 2016 Volume 25, 2015 Volume 24, 2014 Volume 23, 2013 Volume 22, 2012 Volume 21, 2011 Volume 20, 2010 Volume 19, 2009 Volume 18, 2008 Volume 17, 2007 Volume 16, 2006 Volume 15, 2005 Volume 14, 2004 Volume 13, 2003 Volume 12, 2002 Volume 11, 2001 Volume 10, 2000 Volume 9, 1999 Volume 8, 1998 Volume 7, 1997 Volume 6, 1996 Volume 5, 1995 Volume 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v20.i4.30
pages 313-324

Heterotopic Ossification Has Some Nerve

Elizabeth Salisbury
Center for Cell and Gene Therapy; and Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Corinne Sonnet
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Michael Heggeness
Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030, USA
Alan R. Davis
Center for Cell and Gene Therapy; Translational Biology and Molecular Medicine; Department of Orthopedic Surgery; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Elizabeth Olmsted-Davis
Center for Cell and Gene Therapy; Translational Biology and Molecular Medicine; Department of Orthopedic Surgery; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA

RESUMO

Heterotopic ossification, defined as the formation of bone in abnormal anatomic locations, can be clinically insignificant or devastating and debilitating, depending on the site and duration of new bone formation. There are many causes of heterotopic ossification (HO), including soft tissue trauma, central nervous system injury, vasculopathies, arthropathies, and inheritance. One of the least understood components of HO is the interaction of the peripheral nervous system with the induction of this process. Recent work has shown that, upon traumatic injury, a cascade of events termed neurogenic inflammation is initiated, which involves the release of neuropeptides, such as substance P and calcitonin gene related peptide. Release of these peptides ultimately leads to the recruitment of activated platelets, mast cells, and neutrophils to the injury site. These cells appear to be involved with both remodeling of the nerve, as well as potentially recruiting additional cells from the bone marrow to the injury site. Further, sensory neurons stimulated at the injury site relay local information to the brain, which can then redirect neuroendocrine signaling in the hypothalamus towards repair of the injured site. While numerous studies have highlighted the important role of nerve-derived signals, both central and peripheral, in the regulation of normal bone remodeling of the skeleton,1 this review focuses on the role of the local, peripheral nerves in the formation of heterotopic bone. We concentrate on the manner in which local changes in bone morphogenetic protein (BMP) expression contribute to a cascade of events within the peripheral nerves, both sensory and sympathetic, in the immediate area of HO formation.


Articles with similar content:

Inflammation in Ischemic Brain Injury: Timing Is Important
Critical Reviews™ in Neurobiology, Vol.18, 2006, issue 1-2
Jasna Kriz
The Role of Gla Proteins in Vascular Calcification
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 3-4
Afshin Farzaneh-Far , Diane Proudfoot, Catherine M. Shanahan, Peter L. Weissberg
Response of Osteoblasts to the Stimulus of Fluid Flow
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 2
Li Ren, Peng Shang, Peng-Fei Yang, Ling-Wei Huang
RUNX Expression and Function in Human B Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.16, 2006, issue 1
Hannah J. Whiteman, Paul J. Farrell
Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 2
Cheryl Ackert-Bicknell, Juan Pablo Rodriguez, Ana Maria Pino, Clifford J. Rosen