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Critical Reviews™ in Eukaryotic Gene Expression

Publicou 6 edições por ano

ISSN Imprimir: 1045-4403

ISSN On-line: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Modulators of Androgen and Estrogen Receptor Activity

Volume 20, Edição 4, 2010, pp. 275-294
DOI: 10.1615/CritRevEukarGeneExpr.v20.i4.10
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RESUMO

This review focuses on significant recent findings regarding modulators of androgen and estrogen receptor activity. Selective androgen receptor modulators (SARMs) interact with androgen receptors (ARs), and selective estrogen receptor modulators (SERMs) interact with estrogen receptors (ERs), with variable tissue selectivity. SERMs, which interact with both ERб and ERв in a tissue-specific manner to produce diverse outcomes in multiple tissues, continue to generate significant interest for clinical application. Development of SARMs for clinical application has been slower to date because of potential adverse effects, but these diverse compounds continue to be investigated for use in disorders in which modulation of the AR is important. SARMs have been investigated mostly at the basic and preclinical level to date, with few human clinical trials published. These compounds have been evaluated mostly for application in different stages of prostate cancer to date, but they hold promise for multiple other applications. Publication of the large STAR and RUTH clinical trials demonstrated that the SERMs tamoxifen and raloxifene have interesting similarities and differences in tissues that contain ERs. Lasofoxifene, bazedoxifene, and arzoxifene are newer SERMs that have been demonstrated in clinical trials to more potently increase bone mineral density and lower serum cholesterol values than tamoxifen or raloxifene. Both SARMs and SERMs hold great promise for therapeutic use in multiple disorders in which tissue-specific effects are mediated by their respective receptors.

CITADO POR
  1. Yin Liang, Wang Qian, Wang Xiaohui, Song Liang-Nian, Effects of Tribulus terrestris saponins on exercise performance in overtraining rats and the underlying mechanisms, Canadian Journal of Physiology and Pharmacology, 94, 11, 2016. Crossref

  2. Gennari Luigi, Bilezikian John P., New and developing pharmacotherapy for osteoporosis in men, Expert Opinion on Pharmacotherapy, 19, 3, 2018. Crossref

  3. Sfeir Jad G., Drake Matthew T., The Effects of Androgens on Bone Metabolism: Clinical Aspects, in Osteoporosis, 2020. Crossref

  4. Zajac Jeffrey D., Seeman Ego, Russell Nicholas, Ramchand Sabashini K., Bretherton Ingrid, Grossmann Mathis, Davey Rachel A., Testosterone, in Encyclopedia of Bone Biology, 2020. Crossref

  5. Moldogazieva Nurbubu T., Ostroverkhova Daria S., Kuzmich Nikolai N., Kadochnikov Vladimir V., Terentiev Alexander A., Porozov Yuri B., Elucidating Binding Sites and Affinities of ERα Agonists and Antagonists to Human Alpha-Fetoprotein by In Silico Modeling and Point Mutagenesis, International Journal of Molecular Sciences, 21, 3, 2020. Crossref

  6. Gennari Luigi, Bandeira Leonardo, Costa Aline G., Cusano Natalie E., Silva Barbara C., Bilezikian John P., Osteoporosis in Men, in Endocrinology and Diabetes, 2022. Crossref

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