Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v5.i3-4.50
pages 317-335

Transcriptional Control Mechanisms in the Regulation of Cholesterol Balance

Timothy F. Osborne
Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92717-3900

RESUMO

The mechanisms that govern regulation of cholesterol metabolism in higher eukaryotic cells provide an example of how metabolic regulation has evolved to establish growth and nutritional control in a multicellular environment. Two sources of cholesterol must be balanced to ensure optimum growth and viability. Much of the control is established by regulating the levels of key proteins involved in cholesterol uptake and biosynthesis and this occurs by alterations in promoter activity. The studies discussed here track the progression in understanding the mechanism for transcriptional regulation by cholesterol from the isolation of the key genes involved, to the careful dissection of the cis-acting sequences that control expression, and on to what is currently known about the trans-acting proteins that mediate the regulatory response.


Articles with similar content:

Tissue-Specific Transformation by Oncogenic Mutants of Epidermal Growth Factor Receptor
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 4
H. J. Kung, T. H. Carter
Posttranslational Regulation of p53 Tumor Suppressor Protein Function
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 1
Steve A. Maxwell, Jack A. Roth
Structural and Functional Properties of the Actin Gene Family
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 3
Tina M. Bunnell , James M. Ervasti
Chromatin Structure and Nuclear Remodeling
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 3-4
Kristen M. Johansen, Dong Wang, Yanming Wang, Diana L. Walker, Ye Jin, Jorgen Johansen
Cancer and Cancer Stem Cells: New Molecular Perspectives
Critical Reviews™ in Oncogenesis, Vol.24, 2019, issue 1
Onur Sahin, Gokce Ceren Kuscu, Gulperi Oktem, Elif Tunc, Funda Cagirir Dindaroglu, Cevik Gurel, Ismet Hortu, Gizem Inetas, Aylin Buhur