Publicou 6 edições por ano
ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502
Indexed in
Chromatin Domains and Regulation of Gene Expression: Familiar and Enigmatic Clusters of Chicken Globin Genes
RESUMO
Chicken domains of a- and b-globin genes constitute traditional models to study possible relationships between the structural and functional organization of the eukaryotic genome. Recent evidence indicates that these two genomic domains differ significantly in genomic organization as well as in their mode of packaging into chromatin. In this review, we present a comparative analysis of the chicken a- and b-globin gene clusters. The data are discussed in terms of the domain hypothesis of the eukaryotic genome organization. On the basis of the results of our analysis, we present arguments for the existence of three distinct mechanisms that corroborate in the activation/repression of genomic domains. These mechanisms are (1) the relocation of genomic domains into nuclear compartments, (2) the long-term modifications of the mode of chromatin packaging within domains, and (3) the domain activation by continuous action of multiple transcription factors and remodeling complexes.
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Razin Sergey V., Ioudinkova Elena S., Kantidze Omar L., Iarovaia Olga V., Co-Regulated Genes and Gene Clusters, Genes, 12, 6, 2021. Crossref
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Razin Sergey V., Zhegalova Irina V., Kantidze Omar L., Domain Model of Eukaryotic Genome Organization: From DNA Loops Fixed on the Nuclear Matrix to TADs, Biochemistry (Moscow), 87, 7, 2022. Crossref