Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 2.156 FI de cinco anos: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Volumes:
Volume 30, 2020 Volume 29, 2019 Volume 28, 2018 Volume 27, 2017 Volume 26, 2016 Volume 25, 2015 Volume 24, 2014 Volume 23, 2013 Volume 22, 2012 Volume 21, 2011 Volume 20, 2010 Volume 19, 2009 Volume 18, 2008 Volume 17, 2007 Volume 16, 2006 Volume 15, 2005 Volume 14, 2004 Volume 13, 2003 Volume 12, 2002 Volume 11, 2001 Volume 10, 2000 Volume 9, 1999 Volume 8, 1998 Volume 7, 1997 Volume 6, 1996 Volume 5, 1995 Volume 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i4.30
pages 289-297

The Biology of Mycobacterium Cord Factor and Roles in Pathogen-Host Interaction

Chunmei Li
School of Life Sciences
Qinglin Du
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China
Wanyan Deng
Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China
Jianping Xie
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ecoenvironments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China

RESUMO

Mycobacterium cord factor was long held as a virulence factor contributing to the pathogenesis of Mycobacterium tuberculosis. Abundant studies have shed light on its unique chemical structures, metabolism, and receptors on macrophages. The mechanisms underlying cord factor virulence remain elusive. This progress is summarized in this paper, especially the receptors of cord factor, such as Toll-like receptors and Mincle. This might facilitate better use of cord factor as an adjuvant for tuberculosis therapy or selection of drug targets involved in its biosynthesis to combat tuberculosis.


Articles with similar content:

The Critical Role of the Antimicrobial Peptide LL-37/ CRAMP in Protection of Colon Microbiota Balance, Mucosal Homeostasis, Anti-Inflammatory Responses, and Resistance to Carcinogenesis
Critical Reviews™ in Immunology, Vol.39, 2019, issue 2
Weiwei Liang, Wanghua Gong, Keqiang Chen, Ji Ming Wang, Teizo Yoshimura, Meihua Zhang
Brucella Virulence Mechanisms and Implications in Novel Vaccines and Drugs
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 1
Zeliang Chen, Guangjun Gao, Yufei Wang, Xingran Xu, Jie Xu
Autophagy and Autophagy-Related Proteins in the Immunity against Mycobacterium Tuberculosis
Forum on Immunopathological Diseases and Therapeutics, Vol.6, 2015, issue 3-4
Isabelle Vergne, Aïcha Bah
Tuberculosis Resistance and Nanoparticles: Combating the Dual Role of Reactive Oxygen Species in Macrophages for Tuberculosis Management
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.37, 2020, issue 2
Salma Batool, Imran Ali, Hafiz Shoaib Sarwar, Waqas Saleem, Muhammad Farhan Sohail, Sobia Razzaq, Gul Shahnaz, Aisha Rauf, Sara Naveed, Umair Amin, Mubashar Rehman
Mucosal Immunization: A Review of Strategies and Challenges
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 4
Mohan N. Rathi, Hinal Patel, Chetan Yewale, Ambikanandan Misra