Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Eukaryotic Gene Expression
Fator do impacto: 1.841 FI de cinco anos: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN On-line: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v10.i2.30
16 pages

Developmental and Tissue-Specific Regulation of Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene Expression

David Goltzman
Departments of Physiology and Medicine, McGill University; and Calcium Research Laboratory, Royal Victoria Hospital and McGill University, Montreal, Canada
John H. White
Departments of Physiology and Medicine, McGill University, Montreal, Canada


Parathyoid hormone (PTH) and PTH-related peptide (PTHrP) signal through a common PTH/PTHrP receptor (PTHR1). PTH is secreted by the parathyroids and functions in an endocrine manner to regulate extracellular fluid calcium concentrations, largely by interacting with receptors expressed in kidney and bone. PTHrP, on the other hand, is widely expressed and acts by autocrine or paracrine signaling to modulate a range of physiological and developmental responses. PTH1R1 signaling is required both in the adult and during development, and ablation of PTHR1 gene expression results in an embryonic lethal phenotype in both mice and humans. Consequently, the PTHR1 is widely expressed, and transcription of its gene is tissue specific and developmentally regulated. This review focuses on our current knowledge of the mechanisms controlling expression of the PTHR1 gene in humans and in rodents, both during development and in the adult. We also compare the conserved and distinct aspects of PTHR1 gene regulation in the two systems and their bearing on signaling by PTH and PTHrP.

Articles with similar content:

Parathyroid Hormone-Related Peptide (PTHrP) and Parathyroid Hormone (PTH)/PTHrP Receptor
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 3-4
Henry M. Kronenberg, Beate Lanske
TAM Receptors in Leukemia: Expression, Signaling, and Therapeutic Implications
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 1-2
Justine Migdall-Wilson, Douglas K. Graham, Kristen Eisenman, Luis Brandao
YY1 in Cell Differentiation and Tissue Development
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Huating Wang, Fengyuan Chen, Yu Zhao, Hao Sun
Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Mark L. Johnson, Douglas T. Summerfield
Androgen Action
Critical Reviews™ in Eukaryotic Gene Expression, Vol.5, 1995, issue 2
Arun K. Roy, Bandana Chatterjee