Publicou 12 edições por ano
ISSN Imprimir: 1044-5110
ISSN On-line: 1936-2684
Indexed in
TAILORING DRY POWDER INHALER PERFORMANCE BY MODIFYINGCARRIER SURFACE TOPOGRAPHY BY SPRAY DRYING
RESUMO
In order to provide adequate performance of dry powder inhalates with respect to dosing and fine particle fraction, interparticle adhesion between drug and carrier has to be well balanced. It has to be large enough to ensure attachment of the active ingredient during powder handling and dosing, but small enough to ensure detachment of the drug from the carrier on inhalation. In this study, interparticle interactions have been modified by targeting the surface topography of the carrier or rather the contact area between drug and carrier using spray drying. Because lactose is susceptible to spray drying, resulting in partial or full amorphicity, mannitol was used here. The spray drying outlet temperature turned out to be an appropriate parameter to affect surface topography, spray drying at low temperature leading to smooth particles, and spray drying at high temperature leading to rough particle surfaces. Dosing of the inhalate was found not to be affected by surface roughness of the carrier. However, the fine particle fraction decreases with increasing surface roughness. Consequently, the use of mannitol carrier particles exhibiting different surface topographies allows for modifying interparticle interactions, thereby providing an effective tool for tailoring the performance of an inhalate.
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Littringer Eva Maria, Mescher Axel, Eckhard Susanna, Schröttner Hartmuth, Langes Christoph, Fries Manfred, Griesser Ulrich, Walzel Peter, Urbanetz Nora Anne, Spray Drying of Mannitol as a Drug Carrier—The Impact of Process Parameters on Product Properties, Drying Technology, 30, 1, 2012. Crossref
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Mescher Axel, Littringer Eva M., Paus Raphael, Urbanetz Nora A., Walzel Peter, Homogene Produkteigenschaften in der Sprühtrocknung durch laminare Rotationszerstäubung, Chemie Ingenieur Technik, 84, 1-2, 2012. Crossref
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Littringer E.M., Mescher A., Schroettner H., Achelis L., Walzel P., Urbanetz N.A., Spray dried mannitol carrier particles with tailored surface properties – The influence of carrier surface roughness and shape, European Journal of Pharmaceutics and Biopharmaceutics, 82, 1, 2012. Crossref
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Littringer Eva M., Noisternig Michael F., Mescher Axel, Schroettner Hartmuth, Walzel Peter, Griesser Ulrich J., Urbanetz Nora A., The morphology and various densities of spray dried mannitol, Powder Technology, 246, 2013. Crossref
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Littringer E.M., Paus R., Mescher A., Schroettner H., Walzel P., Urbanetz N.A., The morphology of spray dried mannitol particles — The vital importance of droplet size, Powder Technology, 239, 2013. Crossref
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Schoubben Aurélie, Giovagnoli Stefano, Tiralti Maria Cristina, Blasi Paolo, Ricci Maurizio, Capreomycin inhalable powders prepared with an innovative spray-drying technique, International Journal of Pharmaceutics, 469, 1, 2014. Crossref
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Lyu Feng, Liu Jing J., Zhang Yang, Wang Xue Z., Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation, Journal of Crystal Growth, 467, 2017. Crossref
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Mönckedieck M., Kamplade J., Fakner P., Urbanetz N.A., Walzel P., Steckel H., Scherließ R., Dry powder inhaler performance of spray dried mannitol with tailored surface morphologies as carrier and salbutamol sulphate, International Journal of Pharmaceutics, 524, 1-2, 2017. Crossref
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Mönckedieck M., Kamplade J., Fakner P., Urbanetz N. A., Walzel P., Steckel H., Scherließ R., Spray drying of mannitol carrier particles with defined morphology and flow characteristics for dry powder inhalation, Drying Technology, 35, 15, 2017. Crossref
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Saha Jitraj, Kumar Jitendra, Heinrich Stefan, On the approximate solutions of fragmentation equations, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 474, 2209, 2018. Crossref
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Farizhandi Amir Abbas Kazemzadeh, Pacławski Adam, Szlęk Jakub, Mendyk Aleksander, Shao Yu-Hsuan, Lau Raymond, Evaluation of carrier size and surface morphology in carrier-based dry powder inhalation by surrogate modeling, Chemical Engineering Science, 193, 2019. Crossref
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Mönckedieck Mathias, Kamplade Jens, Littringer Eva Maria, Mescher Axel, Gopireddy Srikanth, Hertel Mats, Gutheil Eva, Walzel Peter, Urbanetz Nora Anne, Köster Martin, Steckel Hartwig, Scherließ Regina, Spray Drying Tailored Mannitol Carrier Particles for Dry Powder Inhalation with Differently Shaped Active Pharmaceutical Ingredients, in Process-Spray, 2016. Crossref
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Zhang Fengying, Ngoc Nguyen Thi Quynh, Tay Bao Hui, Mendyk Aleksander, Shao Yu-Hsuan, Lau Raymond, Roughness-Controlled Self-Assembly of Mannitol/LB Agar Microparticles by Polymorphic Transformation for Pulmonary Drug Delivery, Molecular Pharmaceutics, 12, 1, 2015. Crossref
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Abdullahi Hassan, Neoptolemou Petros, Burcham Christopher L., Vetter Thomas, Single droplets to particles - size, shape, shell thickness and porosity analyses using X-ray computed tomography, Chemical Engineering Science, 245, 2021. Crossref
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Padhi Sidhant Satya Prakash, Jimenez Bartolome Miguel, Nyanhongo Gibson Stephen, Schwaiger Nikolaus, Pellis Alessandro, van Herwijnen Hendrikus W. G., Guebitz Georg M., Role of Surface Enhancement in the Enzymatic Cross-Linking of Lignosulfonate Using Alternative Downstream Techniques, ACS Omega, 7, 27, 2022. Crossref
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Yang Yuxin, Liu Jia, Hu Anna, Nie Ting, Cheng Zeneng, Liu Wenjie, A Critical Review on Engineering of d-Mannitol Crystals: Properties, Applications, and Polymorphic Control, Crystals, 12, 8, 2022. Crossref