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Plasma Medicine

Publicou 4 edições por ano

ISSN Imprimir: 1947-5764

ISSN On-line: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

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Selectivity of Non-Thermal Atmospheric-Pressure Microsecond-Pulsed Dielectric Barrier Discharge Plasma Induced Apoptosis in Tumor Cells over Healthy Cells

Volume 1, Edição 3-4, 2011, pp. 249-263
DOI: 10.1615/PlasmaMed.2012004184
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RESUMO

Non-thermal plasma is now being widely investigated for various clinical applications ranging from surface sterilization to blood coagulation to wound healing to cancer therapy. We have shown previously that reactive oxygen species (ROS) generated by non-thermal dielectric barrier discharge (DBD) plasma in the medium surrounding the cells induce DNA damage in mammalian cells, and by tuning the dose, plasma has various effects, from enhancing proliferation to inducing apoptosis in cancer cells.1–3 Although non-thermal plasma primarily produces ROS extracellularly, we hypothesize that it can induce apoptosis in malignant cells similar to ionizing radiation or photodynamic therapy, which primarily produce ROS intracellularly. Unlike ionizing radiation, which damages healthy tissue surrounding the malignant tissue,4,5 or photodynamic therapy, which causes scarring and burning of nearby healthy tissue, non-thermal plasma, due to its non-penetrating nature, may provide a safer means to induce selective apoptosis in malignant tissue by providing precise control of treatment area and depth.

CITADO POR
  1. Ninomiya Kazuaki, Ishijima Tatsuo, Imamura Masatoshi, Yamahara Takayuki, Enomoto Hiroshi, Takahashi Kenji, Tanaka Yasunori, Uesugi Yoshihiko, Shimizu Nobuaki, Evaluation of extra- and intracellular OH radical generation, cancer cell injury, and apoptosis induced by a non-thermal atmospheric-pressure plasma jet, Journal of Physics D: Applied Physics, 46, 42, 2013. Crossref

  2. Joh Hea Min, Kim Sun Ja, Chung T. H., Leem S. H., Comparison of the characteristics of atmospheric pressure plasma jets using different working gases and applications to plasma-cancer cell interactions, AIP Advances, 3, 9, 2013. Crossref

  3. Kaushik Neha, Kumar Naresh, Kim Chung Hyeok, Kaushik Nagendra Kumar, Choi Eun Ha, Dielectric Barrier Discharge Plasma Efficiently Delivers an Apoptotic Response in Human Monocytic Lymphoma, Plasma Processes and Polymers, 11, 12, 2014. Crossref

  4. Ikeda Jun-Ichiro, Tsuruta Yoko, Nojima Satoshi, Sakakita Hajime, Hori Masaru, Ikehara Yuzuru, Anti-Cancer Effects of Nonequilibrium Atmospheric Pressure Plasma on Cancer-Initiating Cells in Human Endometrioid Adenocarcinoma Cells, Plasma Processes and Polymers, 12, 12, 2015. Crossref

  5. Gherardi Matteo, Turrini Eleonora, Laurita Romolo, De Gianni Elena, Ferruzzi Lorenzo, Liguori Anna, Stancampiano Augusto, Colombo Vittorio, Fimognari Carmela, Atmospheric Non-Equilibrium Plasma Promotes Cell Death and Cell-Cycle Arrest in a Lymphoma Cell Line, Plasma Processes and Polymers, 12, 12, 2015. Crossref

  6. Metelmann Hans-Robert, Nedrelow David S., Seebauer Christian, Schuster Matthias, von Woedtke Thomas, Weltmann Klaus-Dieter, Kindler Stefan, Metelmann Philine Henriette, Finkelstein Steven E., Von Hoff Daniel D., Podmelle Fred, Head and neck cancer treatment and physical plasma, Clinical Plasma Medicine, 3, 1, 2015. Crossref

  7. Girard Pierre-Marie, Arbabian Atousa, Fleury Michel, Bauville Gérard, Puech Vincent, Dutreix Marie, Sousa João Santos, Synergistic Effect of H2O2 and NO2 in Cell Death Induced by Cold Atmospheric He Plasma, Scientific Reports, 6, 1, 2016. Crossref

  8. Masur Kai, Immunologie, in Plasmamedizin, 2016. Crossref

  9. Ikeda Jun-ichiro, Tanaka Hiromasa, Ishikawa Kenji, Sakakita Hajime, Ikehara Yuzuru, Hori Masaru, Plasma-activated medium (PAM) kills human cancer-initiating cells, Pathology International, 68, 1, 2018. Crossref

  10. Korotkiy V. N., The use of low-temperature atmospheric plasma in dermatology, Klinicheskaya dermatologiya i venerologiya, 16, 5, 2017. Crossref

  11. Bauer Georg, Sersenová Dominika, Graves David B., Machala Zdenko, Dynamics of Singlet Oxygen-Triggered, RONS-Based Apoptosis Induction after Treatment of Tumor Cells with Cold Atmospheric Plasma or Plasma-Activated Medium, Scientific Reports, 9, 1, 2019. Crossref

  12. Kaushik Nagendra, Kaushik Neha, Linh Nguyen, Ghimire Bhagirath, Pengkit Anchalee, Sornsakdanuphap Jirapong, Lee Su-Jae, Choi Eun, Plasma and Nanomaterials: Fabrication and Biomedical Applications, Nanomaterials, 9, 1, 2019. Crossref

  13. Lafontaine Julie, Boisvert Jean-Sébastien, Glory Audrey, Coulombe Sylvain, Wong Philip, Synergy between Non-Thermal Plasma with Radiation Therapy and Olaparib in a Panel of Breast Cancer Cell Lines, Cancers, 12, 2, 2020. Crossref

  14. Bergemann Claudia, Waldner Anna-Christin, Emmert Steffen, Nebe J. Barbara, The Hyaluronan Pericellular Coat and Cold Atmospheric Plasma Treatment of Cells, Applied Sciences, 10, 15, 2020. Crossref

  15. Bauer Georg, Bekeschus Sander, Biochemistry of Plasma in Cancer Therapy, in Plasma Cancer Therapy, 115, 2020. Crossref

  16. Sklias Kyriakos, Santos Sousa João, Girard Pierre-Marie, Role of Short- and Long-Lived Reactive Species on the Selectivity and Anti-Cancer Action of Plasma Treatment In Vitro, Cancers, 13, 4, 2021. Crossref

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