Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X

Volumes:
Volume 48, 2020 Volume 47, 2019 Volume 46, 2018 Volume 45, 2017 Volume 44, 2016 Volume 43, 2015 Volume 42, 2014 Volume 41, 2013 Volume 40, 2012 Volume 39, 2011 Volume 38, 2010 Volume 37, 2009 Volume 36, 2008 Volume 35, 2007 Volume 34, 2006 Volume 33, 2005 Volume 32, 2004 Volume 31, 2003 Volume 30, 2002 Volume 29, 2001 Volume 28, 2000 Volume 27, 1999 Volume 26, 1998 Volume 25, 1997 Volume 24, 1996 Volume 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v34.i5.10
pages 347-378

Mechanical Impact and Articular Cartilage

C. Corey Scott
Department of Bioengineering, Rice University, Houston, Texas 77251, USA
Kyriacos A. Athanasiou
Department of Bioengineering, Rice University, Houston, Texas, USA

RESUMO

Mechanical impact forces on articular cartilage can cause substantial damage. Car accidents, falls, and sports injuries have a tremendous effect on the U.S. and world populations, both in terms of economic and quality of life costs. While the effects of impact forces are known to be damaging, tolerance levels of cartilage to these forces and the mechanobiologic sequelae are still mostly unknown. Impact studies can be difficult to compare to each other due to the complex array of mechanical factors that are involved in a single impact. Previous work includes mathematical models, acute effects of impact, and in vivo and explant models of impact. These experiments have found that articular cartilage has a threshold above which impact forces are damaging, though this threshold is likely dependent on many factors, both genetic and environmental. This type of damage has been shown to vary according to the severity of the impact, from leaving the articular cartilage surface intact to fracture of the subchondral bone. Some studies have initiated investigations into ways to ameliorate the injurious response to impact, which may allow some patients to avoid the ensuing cartilage degeneration and osteoarthritis. Much work remains to be performed in understanding the genetic and biochemical response to impact. The goal of this research is to eventually decrease the incidence of posttraumatic arthritis and possibly even delay primary osteoarthritis, which can be achieved by using a robust testing design that includes morphological, biomechanical, quantitative biochemical, and genetic characterization of a model system for articular cartilage impact. This model system can then be used to test treatments to prevent degenerative changes in articular cartilage.


Articles with similar content:

The Biomechanics of ACL Injury: Progresses toward Prophylactic Strategies
Critical Reviews™ in Biomedical Engineering, Vol.41, 2013, issue 4-5
Chen-Hua Yeow, Luis Carlos Hernandez Barraza, Jin-Huat Low, Gokula Krishnan. R
A Critical Review of Ankylosing Spondylitis
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.10, 1998, issue 3
Nicola H. Ryall , P. Helliwell
Dental Implantation: An Opportunity to Stop Smoking
Journal of Long-Term Effects of Medical Implants, Vol.22, 2012, issue 4
Fatemeh Mollaverdi, Mahdi Kadkhodazadeh, Omid Amirbandeh, Reza Amid
The Clinical Utility of Pain Behavior Measures
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.12, 2000, issue 3
Patricia Solomon
The Effects of Footwear on Lower Extremity Joint Loading: A Literature Review
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.26, 2014, issue 3-4
Mary Jesse