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Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X

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Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v39.i5.20
pages 363-377

Computational Modeling of Mitochondrial Energy Transduction

J.P.J Schmitz
BioModeling and BioInformatics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands
J. Vanlier
BioModeling and BioInformatics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands;Netherlands Consortium for Systems Biology, the Netherlands
N.A.W. van Riel
BioModeling and BioInformatics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands,Netherlands Consortium for Systems Biology, the Netherlands
Jeroen A.L. Jeneson
Netherlands Consortium for Systems Biology, the Netherlands;Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands. Dr. Jeneson is currently with the Child Development & Exercise Center,

RESUMO

Mitochondria are the power plant of the heart, burning fat and sugars to supply the muscle with the adenosine triphosphate (ATP) free energy that drives contraction and relaxation during each heart beat. This function was first captured in a mathematical model in 1967. Today, interest in such a model has been rekindled by ongoing in silico integrative physiology efforts such as the Cardiac Physiome project. Here, the status of the field of computational modeling of mitochondrial ATP synthetic function is reviewed.


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