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Critical Reviews™ in Biomedical Engineering

Publicou 6 edições por ano

ISSN Imprimir: 0278-940X

ISSN On-line: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Multi-Biomarker Detection Following Traumatic Brain Injury

Volume 47, Edição 3, 2019, pp. 193-206
DOI: 10.1615/CritRevBiomedEng.2019026108
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RESUMO

The Centers for Disease Control and Prevention estimates almost two million traumatic brain injuries (TBIs) occur annually in the U.S., resulting in nearly $80 billion of economic burden. Despite its prevalence, current TBI diagnosis methods mainly rely on cognitive assessments vulnerable to subjective interpretation, thus highlighting the critical need to develop effective unbiased diagnostic methods. The presented study aims to assess the feasibility of a rapid multianalyte TBI blood diagnostic. Specifically, two electrochemical impedance techniques were used to evaluate four biomarkers: glial fibrillary acidic protein, neuron specific enolase (NSE), S-100β, and tumor necrosis factor-α. First, these biomarkers were characterized in purified solutions (detection limit, DL = 2–5 pg/mL), then verified in spiked whole blood and plasma solutions (90% whole blood DL = 14–67 pg/mL). Finally, detection of two of these biomarkers was validated in a controlled cortical impact model of TBI in rats, where a statistical difference between NSE and S-100β concentrations differed several days postinjury (p = 0.02 and p = 0.06, respectively). A statistical difference between mild and moderate injury was found at the various time points. The proposed diagnostic method enabled preliminary quantification of TBI-relevant biomarkers in complex media without the use of expensive electrode coatings or membranes. Collectively, these data demonstrate the feasibility of using electrochemical impedance techniques to rapidly detect TBI biomarkers and lay the groundwork for development of a novel method for quantitative diagnostics of TBI.

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CITADO POR
  1. Strong Madison E., Richards Jeffrey R., Torres Manuel, Beck Connor M., La Belle Jeffrey T., Faradaic electrochemical impedance spectroscopy for enhanced analyte detection in diagnostics, Biosensors and Bioelectronics, 177, 2021. Crossref

  2. Rodríguez Alexander, Burgos-Flórez Francisco, Posada José D., Cervera Eliana, Zucolotto Valtencir, Sanjuán Homero, Sanjuán Marco, Villalba Pedro J., Electrochemical Immunosensor for the Quantification of S100B at Clinically Relevant Levels Using a Cysteamine Modified Surface, Sensors, 21, 6, 2021. Crossref

  3. Pankratova Nadezda, Jović Milica, Pfeifer Marc E., Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application, RSC Advances, 11, 28, 2021. Crossref

  4. Krausz Alyse D., Korley Frederick K., Burns Mark A., The Current State of Traumatic Brain Injury Biomarker Measurement Methods, Biosensors, 11, 9, 2021. Crossref

  5. Wang Kevin K.W., Kobeissy Firas H., Shakkour Zaynab, Tyndall J. Adrian, Thorough overview of ubiquitin C‐terminal hydrolase‐L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury, Acute Medicine & Surgery, 8, 1, 2021. Crossref

  6. Jović Milica, Prim Denis, Saini Edis, Pfeifer Marc Emil, Towards a Point-of-Care (POC) Diagnostic Platform for the Multiplex Electrochemiluminescent (ECL) Sensing of Mild Traumatic Brain Injury (mTBI) Biomarkers, Biosensors, 12, 3, 2022. Crossref

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