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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Imprimir: 0278-940X
ISSN On-line: 1943-619X

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Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v45.i1-6.80
pages 99-110

Study on the Design and Application of Combining Low-Frequency Ultrasound with Laser Radiation in Surgery and Therapy

V. P. Zharov
Biomedical Technical Systems Department, Biomedical Engineering Faculty, N. E. Bauman Moscow State University of Technology, Moscow, Russia
Yu. A. Menyaev
Biomedical Technical Systems Department, Biomedical Engineering Faculty, N. E. Bauman Moscow State University of Technology, Moscow, Russia
R. K. Kabisov
P. A. Gertsen Moscow Research Oncological Institute, Moscow, Russia
S. V. Al'kov
Biomedical Engineering Faculty, N. E. Bauman Moscow State University of Technology, Moscow, Russia
A. V. Nesterov
Biomedical Engineering Faculty, N. E. Bauman Moscow State University of Technology, Moscow, Russia
G. V. Savrasov
Biomedical Engineering Faculty, N. E. Bauman Moscow State University of Technology, Moscow, Russia

RESUMO

Further development of combined laser-ultrasonic medical technologies is presented. An analysis is made of the main effects produced by low-frequency ultrasound on biological tissues. These effects include cavitation, acoustic streamings, acoustic pressure, and mechanical influence. Possible application of low-frequency ultrasound is considered in regard to tumor therapy, bactericidal treatment of infectious tissues, and spray treatment of head and neck wounds. Some limitations of ultrasound application in medicine are discussed, and the feasibility of combining laser radiation with ultrasound is studied. A number of new laser-ultrasonic combinations are put forward and developed. They embrace the combination of photodynamic therapy with ultrasonic tumor therapy (sonophotodynamic therapy), laser-ultrasonic wound treatment (spray treatment), and laser-ultrasonic drug delivery (photophonophoresis). Some of the above-mentioned technologies were tested experimentally, and the results obtained are considered.