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Critical Reviews™ in Therapeutic Drug Carrier Systems
Fator do impacto: 2.9 FI de cinco anos: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X

Volumes:
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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i3.20
36 pages

Drug Delivery Systems for the Treatment of Restenosis

Michael Chorny
Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
Ilia Fishbein
Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
Gershon Golomb
Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel

RESUMO

Attempts to achieve revascularization of coronary arteries blocked by atherosclerotic plaques are hampered by restenotic hyperproliferative response of die treated vessels. The uniform failure of clinical trials using systemic therapies to prevent restenosis has prompted development of methods for arterial drug delivery systems. This review describes technologies of polymeric-based, perivascular, and intraluminal drug and gene delivery systems. The critical assessment of controversies including drug and vehicle type, dose and release rate, and preclinical validation is reviewed.


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