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Critical Reviews™ in Therapeutic Drug Carrier Systems
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ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v24.i4.10
pages 307-360

Spray-Dried Powders for Pulmonary Drug Delivery

Peter C. Seville
Inhalation Technology Research Team, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Hao-ying Li
Inhalation Technology Research Team, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Tristan P. Learoyd
Inhalation Technology Research Team, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK

RESUMO

Powders for inhalation are traditionally prepared using a destructive micronization process such as jet milling to reduce the particle size of the drug to 2−5 μm. The resultant particles are typically highly cohesive and display poor aerosolization properties, necessitating the addition of a coarse carrier particle to the micronized drug to improve powder flowability. Spray-drying technology offers an alternative, constructive particle production technique to the traditional destructive approach, which may be particularly useful when processing biotechnology products that could be adversely affected by high-energy micronization processes. Advantages of spray drying include the ability to incorporate a wide range of excipients into the spray-drying feedstock, which could modify the aerosolization and stability characterizations of the resultant powders, as well as modify the drug release and absorption profiles following inhalation. This review discusses some of the reasons why pulmonary drug delivery is becoming an increasingly popular route of administration and describes the various investigations that have been undertaken in the preparation of spray-dried powders for pulmonary drug delivery.


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