Publicou 6 edições por ano
ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X
Indexed in
Approaches and Opportunities in Colon-Specific Drug Delivery
RESUMO
With the determination of the exact mode of action of sulfasalazine 20 years ago, attention and interest was drawn to the colonic delivery of drugs. A few years before that it became clear that some orally administered laxative drugs are active only after arrival at the large intestine. This resulted in research activity that led to the development of colonic dosage forms. Two major approaches were reported: (1) protective coats that bring the dosage form as close as possible to the colon after oral administration, (2) prodrugs, polymeric prodrugs, and biodegradable polymers that are degraded mostly by the unique enzymes of the colon. Usually, these enzymes are related to the normal colonic microflora. The new drug carriers were examined in vitro and in vivo (laboratory animals). Recently, an increasing number of studies suggest the use of polysaccharide hydrogels for oral delivery of colon-specific drug carriers.
Colonic delivery of drugs is associated with the local delivery of salicylate derivatives to the large intestine for the topical treatment of ulcerative colitis and sometimes the local treatment of irritable bowel syndrome. A common belief is that colonic delivery for orally administered protein drugs is possible because of the postulated low proteolysis activity in the large intestine, an assumption that requires further verification. Yet, other opportunities for colonic delivery of drugs also exist. Some recent examples include bypassing small intestine metabolism, achieving constant absorption rates for some molecules, and delivering cationized antioxidant enzymes to the colonic epithelium.
This article reviews the surge of research activity in the new area of colon-specific drug delivery systems and suggests some possible therapeutic opportunities in this field.
-
Anal Anil Kumar, Controlled-Release Dosage Forms, in Pharmaceutical Sciences Encyclopedia, 2010. Crossref
-
Omwancha Wycliffe S., Mallipeddi Rama, Valle Brenda L., Neau Steven H., Chitosan as a pore former in coated beads for colon specific drug delivery of 5-ASA, International Journal of Pharmaceutics, 441, 1-2, 2013. Crossref
-
Ferrari Priscileila Colerato, Souza Fagner Magalhães, Giorgetti Leandro, Oliveira Giselle Faria, Ferraz Humberto Gomes, Chaud Marco Vinícius, Evangelista Raul Cesar, Development and in vitro evaluation of coated pellets containing chitosan to potential colonic drug delivery, Carbohydrate Polymers, 91, 1, 2013. Crossref
-
Lee Hye J., Choi Chanmi, Oral Delivery of Macromolecules for the Development of Therapeutic Agents, in Pharmaceutical Sciences Encyclopedia, 2011. Crossref
-
Kshirsagar Sanjay J., Bhalekar Mangesh R., Patel Jiten N., Mohapatra Santosh K., Shewale Nitin S., Preparation and characterization of nanocapsules for colon-targeted drug delivery system, Pharmaceutical Development and Technology, 17, 5, 2012. Crossref
-
Zhong Qixin, Shah Bhavini, Surface coating of l-glutamine solid microparticles for enteric delivery, Journal of Food Engineering, 114, 4, 2013. Crossref
-
Mishra R. K., Ramasamy K., Ban N. N., Majeed A. B. A., Synthesis of poly[3-(methacryloylamino) propyl trimethylammonium chloride-co-methacrylic acid] copolymer hydrogels for controlled indomethacin delivery, Journal of Applied Polymer Science, 128, 5, 2013. Crossref
-
Yang Jen Ming, Su Wen Yu, Preparation and characterization of chitosan hydrogel membrane for the permeation of 5-Fluorouracil, Materials Science and Engineering: C, 31, 5, 2011. Crossref
-
Roldo Marta, Barbu Eugen, Brown James F., Laight David W., Smart John D., Tsibouklis John, Orally administered, colon-specific mucoadhesive azopolymer particles for the treatment of inflammatory bowel disease: Anin vivo study, Journal of Biomedical Materials Research Part A, 79A, 3, 2006. Crossref
-
Friend , Review article: issues in oral administration of locally acting glucocorticosteroids for treatment of inflammatory bowel disease, Alimentary Pharmacology & Therapeutics, 12, 7, 1998. Crossref
-
Kumar Samit, Negi Yuvraj Singh, Cellulose and Xylan Based Prodrug of Diclofenac Sodium: Synthesis, Physicochemical Characterization and In Vitro Release, International Journal of Polymeric Materials and Polymeric Biomaterials, 63, 6, 2014. Crossref
-
Rubinstein Abraham, Natural polysaccharides as targeting tools of drugs to the human colon, Drug Development Research, 50, 3-4, 2000. Crossref
-
Bajpai A. K., Bajpai J., Shukla Sandeep, MODULATION OF IN VITRO RELEASE OF CRYSTAL VIOLET FROM A BINARY POLYMER HYDROGEL SYSTEM, Journal of Macromolecular Science, Part A, 39, 5, 2002. Crossref
-
Rane Ashish Babulal, Gattani Surendra Ganeshlal, Kadam Vinayak Dinkar, Tekade Avinash Ramrao, Formulation and Evaluation of Press Coated Tablets for Pulsatile Drug Delivery Using Hydrophilic and Hydrophobic Polymers, Chemical and Pharmaceutical Bulletin, 57, 11, 2009. Crossref
-
Li Jinhe, Yang Libo, Ferguson Sheila M., Hudson Tom J., Watanabe Shunsuke, Katsuma Masataka, Fix Joseph A., In vitro evaluation of dissolution behavior for a colon-specific drug delivery system (CODES™) in multi-pH media using United States Pharmacopeia apparatus II and III, AAPS PharmSciTech, 3, 4, 2002. Crossref
-
Kotla Niranjan Goud, Gulati Monica, Singh Sachin Kumar, Shivapooja Ashwini, Facts, fallacies and future of dissolution testing of polysaccharide based colon-specific drug delivery, Journal of Controlled Release, 178, 2014. Crossref
-
Beglinger C, Poller B, Arbit E, Ganzoni C, Gass S, Gomez-Orellana I, Drewe J, Pharmacokinetics and Pharmacodynamic Effects of Oral GLP-1 and PYY3-36: A Proof-of-concept Study in Healthy Subjects, Clinical Pharmacology & Therapeutics, 84, 4, 2008. Crossref
-
Fan Li-Fang, He Wei, Bai Min, Du Qing, Xiang Bai, Chang Yong-Zhen, Cao De-Ying, Biphasic Drug Release: Permeability and Swelling of Pectin/Ethylcellulose Films, and in Vitro and in Vivo Correlation of Film-Coated Pellets in Dogs, Chemical and Pharmaceutical Bulletin, 56, 8, 2008. Crossref
-
Park Jin Woo, Kim Sang Kyoon, Al-Hilal Taslim Ahmed, Jeon Ok Cheol, Moon Hyun Tae, Byun Youngro, Strategies for oral delivery of macromolecule drugs, Biotechnology and Bioprocess Engineering, 15, 1, 2010. Crossref
-
Meissner Yvette, Lamprecht Alf, Alternative Drug Delivery Approaches for the Therapy of Inflammatory Bowel Disease, Journal of Pharmaceutical Sciences, 97, 8, 2008. Crossref
-
Fish Neil W, Bloor John R, Drug delivery to the colon, Expert Opinion on Therapeutic Patents, 9, 11, 1999. Crossref
-
Flossmann Enrico, Rothwell Peter M, Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies, The Lancet, 369, 9573, 2007. Crossref
-
Gao Song-Qi, Sun Yongen, Kopečková Pavla, Peterson C. Matthew, Kopeček Jindřich, Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer–9-AC Conjugate in Rats, Pharmaceutical Research, 25, 1, 2008. Crossref
-
Muheem Abdul, Shakeel Faiyaz, Jahangir Mohammad Asadullah, Anwar Mohammed, Mallick Neha, Jain Gaurav Kumar, Warsi Musarrat Husain, Ahmad Farhan Jalees, A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives, Saudi Pharmaceutical Journal, 24, 4, 2016. Crossref
-
Crcarevska M. Simonoska, Dodov M. Glavas, Petrusevska G., Gjorgoski I., Goracinova K., Bioefficacy of budesonide loaded crosslinked polyeletrolyte microparticles in rat model of induced colitis, Journal of Drug Targeting, 17, 10, 2009. Crossref
-
Asghar Laila F. A., Chure Chetan B., Chandran Sajeev, Colon Specific Delivery of Indomethacin: Effect of Incorporating pH Sensitive Polymers in Xanthan Gum Matrix Bases, AAPS PharmSciTech, 10, 2, 2009. Crossref
-
Tho Ingunn, Kleinebudde Peter, Sande Sverre Arne, Extrusion/spheronization of pectin-based formulations. I. Screening of important factors, AAPS PharmSciTech, 2, 4, 2001. Crossref
-
Roldo Marta, Barbu Eugen, Brown James F, Laight David W, Smart John D, Tsibouklis John, Azo compounds in colon-specific drug delivery, Expert Opinion on Drug Delivery, 4, 5, 2007. Crossref
-
Gazzaniga Andrea, Maroni Alessandra, Sangalli Maria Edvige, Zema Lucia, Time-controlled oral delivery systems for colon targeting, Expert Opinion on Drug Delivery, 3, 5, 2006. Crossref
-
Karrout Y., Neut C., Wils D., Siepmann F., Deremaux L., Flament M. P., Dubreuil L., Desreumaux P., Siepmann J., Peas starch-based film coatings for site-specific drug delivery to the colon, Journal of Applied Polymer Science, 119, 2, 2011. Crossref
-
Asghar Laila Fatima Ali, Chandran Sajeev, Design and evaluation of matrix base with sigmoidal release profile for colon-specific delivery using a combination of Eudragit and non-ionic cellulose ether polymers, Drug Delivery and Translational Research, 1, 2, 2011. Crossref
-
Wei He, Li-Fang Fan, Yong-Zhen Chang, Bai Xiang, Qing Du, Min Bai, Feng Wang, Min Qing, De-Ying Cao, Pectin/Kollicoat SR30D isolated films for colonic delivery [I]: a comparison of normal and colitis-induced models to assess the efficiency of microbially triggered drug delivery, Journal of Pharmacy and Pharmacology, 61, 2, 2010. Crossref
-
Rubinstein Abraham, Tirosh Boaz, Baluom Muhammad, Nassar Taher, David Ayelet, Radai Raphael, Gliko-Kabir Irit, Friedman Michael, The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools, Journal of Controlled Release, 46, 1-2, 1997. Crossref
-
Gomez-Orellana Isabel, Paton Duncan R, Advances in the oral delivery of proteins, Expert Opinion on Therapeutic Patents, 8, 3, 1998. Crossref
-
Lee Hye J., Protein drug oral delivery: The recent progress, Archives of Pharmacal Research, 25, 5, 2002. Crossref
-
Bharaniraja B., Jayaram Kumar K., Prasad C. M., Sen A. K., Modified katira gum for colon targeted drug delivery, Journal of Applied Polymer Science, 119, 5, 2011. Crossref
-
Kim Duksoo, Hong Sungchae, Jung Sunhwa, Jung Yunjin, Kim Young Mi, Synthesis and Evaluation of N-Nicotinoyl-2-{2-(2-Methyl-5-Nitroimidazol-1-yl)Ethyloxy}-D,L-Glycine as a Colon-Specific Prodrug of Metronidazole, Journal of Pharmaceutical Sciences, 98, 11, 2009. Crossref
-
Klausner Eytan A, Lavy Eran, Friedman Michael, Hoffman Amnon, Expandable gastroretentive dosage forms, Journal of Controlled Release, 90, 2, 2003. Crossref
-
Rodrı́guez Marta, Vila-Jato José L, Torres Dolores, Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region, Journal of Controlled Release, 55, 1, 1998. Crossref
-
Lamprecht Alf, Yamamoto Hiromitsu, Takeuchi Hirofumi, Kawashima Yoshiaki, Design of pH-sensitive microspheres for the colonic delivery of the immunosuppressive drug tacrolimus, European Journal of Pharmaceutics and Biopharmaceutics, 58, 1, 2004. Crossref
-
Thelen Kirstin, Coboeken Katrin, Willmann Stefan, Burghaus Rolf, Dressman Jennifer B., Lippert Jörg, Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions, Journal of Pharmaceutical Sciences, 100, 12, 2011. Crossref
-
Meissner Yvette, Pellequer Yann, Lamprecht Alf, Nanoparticles in inflammatory bowel disease: Particle targeting versus pH-sensitive delivery, International Journal of Pharmaceutics, 316, 1-2, 2006. Crossref
-
Luo Jun-Yong, Zhong Yan, Cao Ji-Chao, Cui Hui-Fei, Efficacy of oral colon-specific delivery capsule of low-molecular-weight heparin on ulcerative colitis, Biomedicine & Pharmacotherapy, 65, 2, 2011. Crossref
-
Lorenzo-Lamosa M.L, Remuñán-López C, Vila-Jato J.L, Alonso M.J, Design of microencapsulated chitosan microspheres for colonic drug delivery, Journal of Controlled Release, 52, 1-2, 1998. Crossref
-
Lai Ping-Shan, Shieh Ming-Jium, Pai Chin-Ling, Wang Cheng-Yi, Young Tai-Horng, A pH-sensitive EVAL membrane by blending with PAA, Journal of Membrane Science, 275, 1-2, 2006. Crossref
-
Whateley Tony L., Literature Alerts, Drug Delivery, 3, 3, 1996. Crossref
-
Wang Jie, Yadav Vipul, Smart Alice L., Tajiri Shinichiro, Basit Abdul W., Stability of peptide drugs in the colon, European Journal of Pharmaceutical Sciences, 78, 2015. Crossref
-
Rubinstein Abraham, Colonic drug delivery, Drug Discovery Today: Technologies, 2, 1, 2005. Crossref
-
Muraoka Motoki, Hu Zhaopeng, Shimokawa Tatsuharu, Sekino Syu-ichi, Kurogoshi Ri-e, Kuboi Yoshiko, Yoshikawa Yukako, Takada Kanji, Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers, Journal of Controlled Release, 52, 1-2, 1998. Crossref
-
Singh Baljit, Chauhan G.S., Sharma D.K., Kant Anil, Gupta I., Chauhan Nirmala, The release dynamics of model drugs from the psyllium and N-hydroxymethylacrylamide based hydrogels, International Journal of Pharmaceutics, 325, 1-2, 2006. Crossref
-
Orienti I., Cerchiara T., Luppi B., Bigucci F., Zuccari G., Zecchi V., Influence of different chitosan salts on the release of sodium diclofenac in colon-specific delivery, International Journal of Pharmaceutics, 238, 1-2, 2002. Crossref
-
Yang Jen Ming, Su Wen Yu, Leu Te Lang, Yang Ming Chien, Evaluation of chitosan/PVA blended hydrogel membranes, Journal of Membrane Science, 236, 1-2, 2004. Crossref
-
El-Hag Ali A., AlArifi A. S., Swelling and drug release profile of poly(2-ethyl-2-oxazoline)-based hydrogels prepared by gamma radiation-induced copolymerization, Journal of Applied Polymer Science, 120, 5, 2011. Crossref
-
Alvarez-Fuentes J., Fernández-Arévalo M., González-Rodríguez M.L., Cirri M., Mura P., Development of Enteric-coated Timed-release Matrix Tablets for Colon Targeting, Journal of Drug Targeting, 12, 9-10, 2004. Crossref
-
Gadalla Hytham H., Soliman Ghareb M., Mohammed Fergany A., El-Sayed Ahmed M., Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone, Drug Delivery, 23, 7, 2016. Crossref
-
Ali Asghar Laila Fatima, Azeemuddin Md., Jain Varun, Chandran Sajeev, Design and in vitro evaluation of formulations with pH and transit time controlled sigmoidal release profile for colon-specific delivery, Drug Delivery, 16, 6, 2009. Crossref
-
Singh Sachin Kumar, Yadav Ankit Kumar, Prudhviraj G., Gulati Monica, Kaur Puneet, Vaidya Yogyata, A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice, European Journal of Pharmaceutical Sciences, 73, 2015. Crossref
-
Manocha Marcus, Khan Waliul I, Serotonin and GI Disorders: An Update on Clinical and Experimental Studies, Clinical and Translational Gastroenterology, 3, 4, 2012. Crossref
-
Sinha V.R, Kumria Rachna, Microbially triggered drug delivery to the colon, European Journal of Pharmaceutical Sciences, 18, 1, 2003. Crossref
-
Sinha V. R., Bhinge J. R., Kumria Rachna, Kumar Manoj, Development of Pulsatile Systems for Targeted Drug Delivery of Celecoxib for Prophylaxis of Colorectal Cancer, Drug Delivery, 13, 3, 2006. Crossref
-
Shi Xin-Yuan, Tan Tian-Wei, Preparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of Vitamin D2, Biomaterials, 23, 23, 2002. Crossref
-
Yang Libo, Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora, Journal of Controlled Release, 125, 2, 2008. Crossref
-
Sintov Amnon, Simberg Mark, Rubinstein Abraham, Absorption enhancement of captopril in the rat colon as a putative method for captopril delivery by extended release formulations, International Journal of Pharmaceutics, 143, 1, 1996. Crossref
-
Nykänen P, Lempää S, Aaltonen M.-L, Jürjenson H, Veski P, Marvola M, Citric acid as excipient in multiple-unit enteric-coated tablets for targeting drugs on the colon, International Journal of Pharmaceutics, 229, 1-2, 2001. Crossref
-
Gliko-Kabir Irit, Penhasi Adel, Rubinstein Abraham, Characterization of crosslinked guar by thermal analysis, Carbohydrate Research, 316, 1-4, 1999. Crossref
-
Vashisth Priya, Singh Harmeet, Pruthi Parul A., Pruthi Vikas, Gellan as Novel Pharmaceutical Excipient, in Handbook of Polymers for Pharmaceutical Technologies, 2015. Crossref
-
Marvola M., Nykänen P., Rautio S., Isonen N., Autere A.-M., Enteric polymers as binders and coating materials in multiple-unit site-specific drug delivery systems, European Journal of Pharmaceutical Sciences, 7, 3, 1999. Crossref
-
Löbenberg Raimar, Kim Jae Seung, Amidon Gordon L., Pharmacokinetics of an immediate release, a controlled release and a two pulse dosage form in dogs, European Journal of Pharmaceutics and Biopharmaceutics, 60, 1, 2005. Crossref
-
Mura Paola, Maestrelli Francesca, Cirri Marzia, Luisa González Rodríguez M., Rabasco Alvarez Antonio M., Development of Enteric-coated Pectin-based Matrix Tablets for Colonic Delivery of Theophylline, Journal of Drug Targeting, 11, 6, 2003. Crossref
-
Nadler Milabuer Mirela, Kam Yossi, Rubinstein Abraham, Orally Administered Drug Delivery Systems to the Colon, in Oral Controlled Release Formulation Design and Drug Delivery, 2010. Crossref
-
Singh Baljit, Chauhan G.S., Sharma D.K., Chauhan Nirmala, The release dynamics of salicylic acid and tetracycline hydrochloride from the psyllium and polyacrylamide based hydrogels (II), Carbohydrate Polymers, 67, 4, 2007. Crossref
-
Cerchiara Teresa, Bigucci Federica, Corace Giuseppe, Zecchi Vittorio, Luppi Barbara, Eudragit-coated albumin nanospheres carrying inclusion complexes for oral administration of indomethacin, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 71, 1-2, 2011. Crossref
-
Gebhardt Rolf, Hengstler Jan G., Müller Dieter, Glöckner Reinhild, Buenning Peter, Laube Britta, Schmelzer Eva, Ullrich Martina, Utesch Dietmar, Nicola Hewitt , Ringel Michael, Hilz Beate Reder, Bader Augustinus, Langsch Angelika, Koose Thomas, Burger Hans-Jörg, Maas Jochen, Oesch Franz, New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures, Drug Metabolism Reviews, 35, 2-3, 2003. Crossref
-
Giammona G, Pitarresi G, Tomarchio V, Cacciaguerra S, Govoni P, A Hydrogel Based on a Polyaspartamide: Characterization and Evaluation of In-vivo Biocompatibility and Drug Release in the Rat, Journal of Pharmacy and Pharmacology, 49, 11, 2011. Crossref
-
Prudhviraj G., Vaidya Yogyata, Singh Sachin Kumar, Yadav Ankit Kumar, Kaur Puneet, Gulati Monica, Gowthamarajan K., Effect of co-administration of probiotics with polysaccharide based colon targeted delivery systems to optimize site specific drug release, European Journal of Pharmaceutics and Biopharmaceutics, 97, 2015. Crossref
-
Lamprecht Alf, Yamamoto Hiromitsu, Takeuchi Hirofumi, Kawashima Yoshiaki, pH-sensitive microsphere delivery increases oral bioavailability of calcitonin, Journal of Controlled Release, 98, 1, 2004. Crossref
-
Yang Libo, Chu James S, Fix Joseph A, Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation, International Journal of Pharmaceutics, 235, 1-2, 2002. Crossref
-
Dahan Arik, Duvdevani Revital, Dvir Eran, Elmann Anat, Hoffman Amnon, A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: In-vivo and in-vitro evaluation of an indomethacin–lecithin conjugate, Journal of Controlled Release, 119, 1, 2007. Crossref
-
Lamprecht Alf, Yamamoto Hiromitsu, Takeuchi Hirofumi, Kawashima Yoshiaki, A pH-sensitive microsphere system for the colon delivery of tacrolimus containing nanoparticles, Journal of Controlled Release, 104, 2, 2005. Crossref
-
Asghar Laila Fatima Ali, Chandran Sajeev, Design and evaluation of matrices of Eudragit with polycarbophil and carbopol for colon-specific delivery, Journal of Drug Targeting, 16, 10, 2008. Crossref
-
Friend David R., New oral delivery systems for treatment of inflammatory bowel disease, Advanced Drug Delivery Reviews, 57, 2, 2005. Crossref
-
Fagerholm Urban, Sjöström Brita, Sroka-Markovic Janina, Wijk Annika, Svensson Marianne, Lennernäs Hans, The Effect of a Drug-delivery System Consisting of Soybean Phosphatidyl Choline and Medium-chain Monoacylglycerol on the Intestinal Permeability of Hexarelin in the Rat, Journal of Pharmacy and Pharmacology, 50, 5, 2011. Crossref
-
Lamprecht A., Kawashima Y., pH-sensitive microparticles for oral drug delivery, Journal of Drug Delivery Science and Technology, 16, 1, 2006. Crossref
-
Asghar Laila Fatima Ali, Azeemuddin Md, Jain Varun, Chandran Sajeev, Design and in vitro evaluation of formulations with pH and transit time controlled sigmoidal release profile for colon-specific delivery, Drug Delivery, 16, 4, 2009. Crossref
-
Hu Zhaopeng, Kimura Go, Mawatari Shun-suke, Shimokawa Tatsuhiro, Yoshikawa Yukako, Takada Kanji, New preparation method of intestinal pressure-controlled colon delivery capsules by coating machine and evaluation in beagle dogs, Journal of Controlled Release, 56, 1-3, 1998. Crossref
-
Gao Song-Qi, Lu Zheng-Rong, Kopečková Pavla, Kopeček Jindřich, Biodistribution and pharmacokinetics of colon-specific HPMA copolymer–9-aminocamptothecin conjugate in mice, Journal of Controlled Release, 117, 2, 2007. Crossref
-
Gupta Vishal K., Beckert Thomas E., Deusch Norbert J., Hariharan Madhusudan, Price James C., Investigation of Potential Ionic Interactions Between Anionic and Cationic Polymethacrylates of Multiple Coatings of Novel Colonic Delivery System, Drug Development and Industrial Pharmacy, 28, 2, 2002. Crossref
-
Minami Kunihiro, Hirayama Fumitoshi, Uekama Kaneto, Colon-Specific Drug Delivery Based on a Cyclodextrin Prodrug: Release Behavior of Biphenylylacetic Acid from Its Cyclodextrin Conjugates in Rat Intestinal Tracts after Oral Administration, Journal of Pharmaceutical Sciences, 87, 6, 1998. Crossref
-
Bajpai S.K., Singh Surinderpal, Bajpai M., Carbohydrate Polymers: Colon-Targeted Drug Delivery, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2016. Crossref
-
Sinha V. R., Kumria Rachna, Polysaccharide Matrices for Microbially Triggered Drug Delivery to the Colon, Drug Development and Industrial Pharmacy, 30, 2, 2004. Crossref
-
Sadeghi Meisam, Hanifpour Fatemeh, Taheri Reza, Javadian Hamedreza, Ghasemi Maryam, Comparison of using formaldehyde and carboxy methyl chitosan in preparation of Fe3O4 superparamagnetic nanoparticles-chitosan hydrogel network: Sorption behavior toward bovine serum albumin, Process Safety and Environmental Protection, 102, 2016. Crossref
-
Ferrari Priscileila Colerato, Prezotti Fabiola Garavello, Ferreira Cury Beatriz Stringhetti, Evangelista Raul Cesar, Colonic Drug Delivery: Biopolymers and Enteric Polymers, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2016. Crossref
-
Rodriguez Marta, Antúnez José Antonio, Taboada Cristina, Seijo Begoña, Torres Dolores, Colon-specific delivery of budesonide from microencapsulated cellulosic cores: evaluation of the efficacy against colonic inflammation in rats, Journal of Pharmacy and Pharmacology, 53, 9, 2010. Crossref
-
Tozaki Hideyuki, Nishioka Junko, Komoike Junta, Okada Naoki, Fujita Takuya, Muranishi Shozo, Kim Sooh‐Ih, Terashima Hiroshi, Yamamoto Akira, Enhanced Absorption of Insulin and (Asu1,7)Eel‐Calcitonin using Novel Azopolymer‐Coated Pellets for Colon‐Specific Drug Delivery, Journal of Pharmaceutical Sciences, 90, 1, 2001. Crossref
-
Shah Nitesh, Shah Tejal, Amin Avani, Polysaccharides: a targeting strategy for colonic drug delivery, Expert Opinion on Drug Delivery, 8, 6, 2011. Crossref
-
Qi Meiling, Wang Peng, Wu Dezheng, A Novel pH- and Time-Dependent System for Colonic Drug Delivery, Drug Development and Industrial Pharmacy, 29, 6, 2003. Crossref
-
Chandran Sajeev, Sanjay Kango Surbhi, Ali Asghar Laila Fatima, Microspheres with pH modulated release: Design and characterization of formulation variables for colonic delivery, Journal of Microencapsulation, 26, 5, 2009. Crossref
-
Oz Helieh, Ebersole Jeffrey, Application of Prodrugs to Inflammatory Diseases of the Gut, Molecules, 13, 2, 2008. Crossref
-
Omwancha Wycliffe, Kouba Chahinaz, Yelamanchili Satish, Neau Steven H., Colon-specific drug delivery using ethylcellulose and chitosan in the coat of compression-coated tablets, Drug Development and Industrial Pharmacy, 37, 8, 2011. Crossref
-
Nguyen Minh Ngoc-Uyen, Vo Van Toi, Tran Phuong Ha-Lien, Tran Thao Truong-Dinh, Development of a Zein-Based System for Colon Specific Delivery, in 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6), 63, 2018. Crossref
-
Ren Yachao, Jiang Lei, Yang Shuman, Gao Sainan, Yu Hui, Hu Jie, Hu Dandan, Mao Wenbin, Peng Haisheng, Zhou Yulong, Design and preparation of a novel colon-targeted tablet of hydrocortisone, Brazilian Journal of Pharmaceutical Sciences, 52, 2, 2016. Crossref
-
Ren Yachao, Jiang Lei, Yang Shuman, Gao Sainan, Yu Hui, Hu Jie, Hu Dandan, Mao Wenbin, Peng Haisheng, Zhou Yulong, Design and preparation of a novel colon-targeted tablet of hydrocortisone, Brazilian Journal of Pharmaceutical Sciences, 53, 1, 2017. Crossref
-
Goldberg Michael, Gomez-Orellana Isabel, Challenges for the oral delivery of macromolecules, Nature Reviews Drug Discovery, 2, 4, 2003. Crossref
-
Tambe Srushti M., Desai Namita D., Colonic Bacterial Enzymes, in Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology, 2018. Crossref
-
Stealey Samuel, Guo Xiaoru, Majewski Rebecca, Dyble Alexander, Lehman Kendra, Wedemeyer Michael, Steeber Douglas A., Kaltchev Matey G., Chen Junhong, Zhang Wujie, Calcium-oligochitosan-pectin microcarrier for colonic drug delivery, Pharmaceutical Development and Technology, 25, 2, 2020. Crossref
-
Basit Abdul W, Advances in Colonic Drug Delivery, Drugs, 65, 14, 2005. Crossref
-
Nguyen Minh N.U., Tran Phuong H.L., Tran Thao T.D., A single-layer film coating for colon-targeted oral delivery, International Journal of Pharmaceutics, 559, 2019. Crossref
-
Lamprecht Alf, Yamamoto Hiromitsu, Ubrich Nathalie, Takeuchi Hirofumi, Maincent Philippe, Kawashima Yoshiaki, FK506 Microparticles Mitigate Experimental Colitis with Minor Renal Calcineurin Suppression, Pharmaceutical Research, 22, 2, 2005. Crossref
-
Hirayama Fumitoshi, Uekama Kaneto, Colonic Delivery, in Prodrugs, V, 2007. Crossref
-
Ma Zhengang, Ma Rui, Wang Xue, Gao Jinlai, Zheng Yufeng, Sun Zhijie, Enzyme and PH responsive 5-flurouracil (5-FU) loaded hydrogels based on olsalazine derivatives for colon-specific drug delivery, European Polymer Journal, 118, 2019. Crossref
-
Kumar Ankit, Gulati Monica, Singh Sachin Kumar, Gowthamarajan K., Prashar Rahul, Mankotia Diksha, Gupta Jay Prakash, Banerjee Mayukh, Sinha Shubham, Awasthi Ankit, Corrie Leander, Kumar Rajan, Patni Pooja, Kumar Bimlesh, Pandey Narendra Kumar, Sadotra Manik, Kumar Pardeep, Kumar Rajesh, Wadhwa Sheetu, Khursheed Rubiya, Effect of co-administration of probiotics with guar gum, pectin and eudragit S100 based colon targeted mini tablets containing 5-Fluorouracil for site specific release, Journal of Drug Delivery Science and Technology, 60, 2020. Crossref
-
Balant Luc P., Metabolic Considerations in Prodrug Design, in Burger's Medicinal Chemistry and Drug Discovery, 2003. Crossref
-
Urtiga Silvana Cartaxo da Costa, Alves Vitória Maria Oliveira, Melo Camila de Oliveira, Lima Marini Nascimento de, Souza Ernane, Cunha Arcelina Pacheco, Ricardo Nágila Maria Pontes Silva, Oliveira Elquio Eleamen, Egito Eryvaldo Sócrates Tabosa do, Xylan microparticles for controlled release of mesalamine: Production and physicochemical characterization, Carbohydrate Polymers, 250, 2020. Crossref
-
Du Xuewen, Zhou Jie, Shi Junfeng, Xu Bing, Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials, Chemical Reviews, 115, 24, 2015. Crossref
-
Willmann Stefan, Schmitt Walter, Keldenich Jörg, Lippert Jörg, Dressman Jennifer B., A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans, Journal of Medicinal Chemistry, 47, 16, 2004. Crossref
-
Bisht S, Bajaj H, COLON TARGETING APPROACHES: PAST, PRESENT AND FUTURE, INDIAN DRUGS, 49, 03, 2012. Crossref
-
Pahwa Rakesh, Bajaj Ridhi, Bhateja Pankaj, Piplani Mona, Recent Advances in Colon Drug Delivery Technology, Drug Delivery Letters, 11, 2, 2021. Crossref
-
Orlu Mine, Cevher Erdal, Araman Ahmet, Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges, International Journal of Pharmaceutics, 318, 1-2, 2006. Crossref
-
Haimer Emmerich, Liebner Falk, Potthast Antje, Rosenau Thomas, Micro‐ and Nanoparticles from Hemicelluloses, in Polysaccharide Building Blocks, 2012. Crossref
-
Devi K. Tirumala, Venkateswarlu B. S., Umamaheswari D., Vijay Sankar G. R., Prasanthi N. Lakshmi, Design and Development of Ornidazole Loaded Polymeric Nanoparticles, Research Journal of Pharmacy and Technology, 2022. Crossref
-
Sun Mengchi, Ban Weiyue, Ling Hao, Yu Xiang, He Zhonggui, Jiang Qikun, Sun Jin, Emerging nanomedicine and prodrug delivery strategies for the treatment of inflammatory bowel disease, Chinese Chemical Letters, 33, 10, 2022. Crossref
-
Tran Phuong H.L., Tran Thao T.D., Current Film Coating Designs for Colon-Targeted Oral Delivery, Current Medicinal Chemistry, 28, 10, 2021. Crossref