Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Therapeutic Drug Carrier Systems
Fator do impacto: 2.9 FI de cinco anos: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X

Volumes:
Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v29.i2.20
pages 149-182

Drug-Loaded PLGA Nanoparticles for Oral Administration: Fundamental Issues and Challenges Ahead

Gaurav Kumar
Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai-410210, India
Nusrat Shafiq
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
Samir Malhotra
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India

RESUMO

Drug-loaded polylactide-co-glycolide (PLGA) nanoparticles have been extensively studied and have a practical impact on drug delivery. Many PLGA-based nanoformulations have reached different stages of preclinical development; however, they present distinct challenges for researchers. This review discusses some of the challenges and issues involved in selecting drug and polymer combinations for encapsulation, aggregation of nanoparticles during characterization in in vitro studies, sterilization, and long-term stability of drug-loaded nanoparticles. We include recommendations to overcome these challenges.


Articles with similar content:

Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Swarna Bale, Mandip Singh, A. Shiva Shankar Reddy, Amit Khurana, Chandraiah Godugu
Nanosuspensions in Drug Delivery: Recent Advances, Patent Scenarios, and Commercialization Aspects
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 5
Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan
PLGA Nanoparticles in Drug Delivery: The State of the Art
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 5
Sarita Hariharan, Indu Bala, M. N. V. Ravi Kumar
Engineered PLGA Nanoparticles: An Emerging Delivery Tool in Cancer Therapeutics
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 1
Amit K. Jain, Manasmita Das, Nitin K. Swarnakar, Sanyog Jain
Polyhedral Oligomeric Silsesquioxane Poly(Carbonate-Urea) Urethane (POSS-PCU): Applications in Nanotechnology and Regenerative Medicine
Critical Reviews™ in Biomedical Engineering, Vol.41, 2013, issue 6
Yasmin Farhatnia, Aaron Tan, Alexander M. Seifalian