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Critical Reviews™ in Therapeutic Drug Carrier Systems
Fator do impacto: 2.9 FI de cinco anos: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimir: 0743-4863
ISSN On-line: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i5.20
42 pages

Regional Variation in Oral Mucosal Drug Permeability

Yuji Kurosaki
Graduate School of Natural Science and Technology, Okayama University, Tsushima-naka 1-1-1, Okayama 700-8530, Japan
Toshikiro Kimura
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka 1-1-1, Okayama 700-8530, Japan

RESUMO

The purpose of this article is to review regional variation in oral mucosal drug permeability. The structure and composition of the mucosa at different sites in the oral cavity, factors affecting mucosal permeability, selection of appropriate experimental systems for studying mucosal permeability, and formulation factors including penetration enhancement relevant to the design of systems for oral mucosal delivery are reviewed.