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Critical Reviews™ in Immunology

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ISSN Imprimir: 1040-8401

ISSN On-line: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Multiple Defects of Natural Killer Cells in Cancer Patients: Anarchy, Dysregulated Systemic Immunity, and Immunosuppression in Metastatic Cancer

Volume 40, Edição 2, 2020, pp. 93-133
DOI: 10.1615/CritRevImmunol.2020033391
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RESUMO

We have previously demonstrated that natural killer (NK) cells are the main immune effectors that can mediate selection and differentiation of different cancer stem cells and undifferentiated tumors via lysis and secreted or membrane-bound interferon-γ and tumor necrosis factor-α, respectively. This leads to growth inhibition and tumor metastasis curtailment. In this review, we present an overview of our findings on NK cell biology and its significance in selection and differentiation of stem-like tumors using in vitro and in vivo studies conducted in nonobese diabetic/severe combined immunodeficiency (scid)/interleukin-Rγ--, humanized−bone-marrow/liver/thymus (hu-BLT) mice, and those of human cancer patients. Moreover, we present recent advances in NK cell expansion and therapeutic delivery and discuss the superiority of allogeneic supercharged NK cells over their autologous counterparts for cancer treatment. We review potential loss of NK cell numbers and function at neoplastic and preneoplastic stages of tumorigenesis as a potential mechanism for pancreatic cancer induction and progression. We believe that NK cells should be placed highly in the armamentarium of tumor immunotherapy due to their indispensable role in targeting cancer stem-like/poorly differentiated tumors and a variety of other key NK cell functions that are discussed in this report, including their role in CD8+ T-cell expansion and targeting gene knockout or dedifferentiated tumors. The combination of allogeneic supercharged NK cells and other immunotherapeutic strategies such as oncolytic viruses, antibody-dependent cellular cytotoxicity-inducing antibodies, checkpoint inhibitors, chimeric antigen receptor (CAR)-T cells and CAR-NK cells, chemotherapeutics, and radiotherapeutic strategies can be used for optimal eradication of tumors.

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CITADO POR
  1. Lah Turnšek Tamara, Jiao Xuanmao, Novak Metka, Jammula Sriharsha, Cicero Gina, Ashton Anthony W., Joyce David, Pestell Richard G., An Update on Glioblastoma Biology, Genetics, and Current Therapies: Novel Inhibitors of the G Protein-Coupled Receptor CCR5, International Journal of Molecular Sciences, 22, 9, 2021. Crossref

  2. Majc Bernarda, Novak Metka, Kopitar-Jerala Nataša, Jewett Anahid, Breznik Barbara, Immunotherapy of Glioblastoma: Current Strategies and Challenges in Tumor Model Development, Cells, 10, 2, 2021. Crossref

  3. Jewett Anahid, Kos Janko, Turnsek Tamara Lah, Chen Po-Chun, Breznik Barbara, Senjor Emanuela, Chovatiya Nishant, Kaur Kawaljit, Ko Meng-Wei, Novel strategies to expand supercharged NK cells with augmented capacity to withstand inactivation by tumors, in Successes and Challenges of NK Immunotherapy, 2021. Crossref

  4. Jakoš Tanja, Prunk Mateja, Pišlar Anja, Kos Janko, Cathepsin X Activity Does Not Affect NK-Target Cell Synapse but Is Rather Distributed to Cytotoxic Granules, International Journal of Molecular Sciences, 22, 24, 2021. Crossref

  5. Chovatiya Nishant, Kaur Kawaljit, Huerta-Yepez Sara, Chen Po-Chun, Neal Adam, DiBernardo Gabriella, Gumrukcu Serhat, Memarzadeh Sanaz, Jewett Anahid, Inability of ovarian cancers to upregulate their MHC-class I surface expression marks their aggressiveness and increased susceptibility to NK cell-mediated cytotoxicity, Cancer Immunology, Immunotherapy, 2022. Crossref

  6. Ko Meng-Wei, Breznik Barbara, Senjor Emanuela, Jewett Anahid, Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells, Advances in Cancer Biology - Metastasis, 5, 2022. Crossref

  7. Kaur Kawaljit, Chen Po-Chun, Ko Meng-Wei, Mei Ao, Chovatiya Nishant, Huerta-Yepez Sara, Ni Weiming, Mackay Sean, Zhou Jing, Maharaj Dipanarine, Malarkannan Subramaniam, Jewett Anahid, The Potential Role of Cytotoxic Immune Effectors in Induction, Progression and Pathogenesis of Amyotrophic Lateral Sclerosis (ALS), Cells, 11, 21, 2022. Crossref

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