Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell−Based Immunotherapy
RESUMO
Natural killer (NK) cells are critical immune effector cells capable of mediating antitumor responses. These cytotoxic lymphocytes recognize transformed cells through a mechanism mainly dependent on the engagement of several activating receptors. However, many tumors have developed strategies to evade immunosurveillance and detection by NK cells. A relevant immune escape mechanism is the down regulation of NK cell activating ligands on the surface of tumor cells by proteolytic shedding mediated by different members of metalloproteinase families. Here, we consider two important NK activating receptors, namely NKG2D and NKp30, the ligands (i.e., MICA/B, ULBPs, and B7-H6) of which can be released by cancer cells through proteolytic cleavage. Modulation of ligand shedding in response to cancer therapy is also examined, and we discuss how metalloproteinases implicated in the ligand cleavage could be targeted in novel therapeutic schemes to counteract tumor escape from stress-elicited immune responses.
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Zingoni Alessandra, Fionda Cinzia, Borrelli Cristiana, Cippitelli Marco, Santoni Angela, Soriani Alessandra, Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance, Frontiers in Immunology, 8, 2017. Crossref
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Bruno Antonino, Bassani Barbara, D'Urso Davide Giuseppe, Pitaku Ilvana, Cassinotti Elisa, Pelosi Giuseppe, Boni Luigi, Dominioni Lorenzo, Noonan Douglas M., Mortara Lorenzo, Albini Adriana, Angiogenin and the MMP9‐TIMP2 axis are up‐regulated in proangiogenic, decidual NK‐like cells from patients with colorectal cancer, The FASEB Journal, 32, 10, 2018. Crossref
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Chiossone Laura, Dumas Pierre-Yves, Vienne Margaux, Vivier Eric, Natural killer cells and other innate lymphoid cells in cancer, Nature Reviews Immunology, 18, 11, 2018. Crossref
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Zingoni Alessandra, Molfetta Rosa, Fionda Cinzia, Soriani Alessandra, Paolini Rossella, Cippitelli Marco, Cerboni Cristina, Santoni Angela, NKG2D and Its Ligands: “One for All, All for One”, Frontiers in Immunology, 9, 2018. Crossref
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Zingoni Alessandra, Vulpis Elisabetta, Cecere Francesca, Amendola Maria G., Fuerst Daniel, Saribekyan Taron, Achour Adnane, Sandalova Tatyana, Nardone Ilaria, Peri Agnese, Soriani Alessandra, Fionda Cinzia, Mariggiò Elena, Petrucci Maria T., Ricciardi Maria R., Mytilineos Joannis, Cippitelli Marco, Cerboni Cristina, Santoni Angela, MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma, Frontiers in Immunology, 9, 2018. Crossref
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Riera-Domingo Carla, Audigé Annette, Granja Sara, Cheng Wan-Chen, Ho Ping-Chih, Baltazar Fátima, Stockmann Christian, Mazzone Massimiliano, Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy, Physiological Reviews, 100, 1, 2020. Crossref
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Hodgins Jonathan J., Khan Sarwat T., Park Maria M., Auer Rebecca C., Ardolino Michele, Killers 2.0: NK cell therapies at the forefront of cancer control, Journal of Clinical Investigation, 129, 9, 2019. Crossref
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Molfetta Rosa, Zingoni Alessandra, Santoni Angela, Paolini Rossella, Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention, Frontiers in Immunology, 10, 2019. Crossref
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Moloudizargari Milad, Abdollahi Mohammad, Asghari Mohammad Hossein, Zimta Alina Andreea, Neagoe Ioana Berindan, Nabavi Seyed Mohammad, The emerging role of exosomes in multiple myeloma, Blood Reviews, 38, 2019. Crossref
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Antonangeli Fabrizio, Zingoni Alessandra, Soriani Alessandra, Santoni Angela, Senescent cells: Living or dying is a matter of NK cells, Journal of Leukocyte Biology, 105, 6, 2019. Crossref
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Khan Muhammad, Arooj Sumbal, Wang Hua, NK Cell-Based Immune Checkpoint Inhibition, Frontiers in Immunology, 11, 2020. Crossref
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Frazao Alexandra, Rethacker Louise, Jeudy Géraldine, Colombo Marina, Pasmant Eric, Avril Marie-Françoise, Toubert Antoine, Moins-Teisserenc Helene, Roelens Marie, Dalac Sophie, Maubec Eve, Caignard Anne, BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis, Journal for ImmunoTherapy of Cancer, 8, 2, 2020. Crossref
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Yunus Muhammad Amir, Ramli Muhammad Mahyiddin, Osman Nurul Huda, Mohamed Rafeezul, Stimulation of Innate and Adaptive Immune Cells with Graphene Oxide and Reduced Graphene Oxide Affect Cancer Progression, Archivum Immunologiae et Therapiae Experimentalis, 69, 1, 2021. Crossref
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Hamilton Gerhard, Plangger Adelina, The Impact of NK Cell-Based Therapeutics for the Treatment of Lung Cancer for Biologics: Targets and Therapy, Biologics: Targets and Therapy, Volume 15, 2021. Crossref
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Tang Ying, Jiang Mei, Jiang Hai-Mei, Ye Zeng Jie, Huang Yu-Sheng, Li Xiu-Shen, Qin Bin-Yu, Zhou Rui-Sheng, Pan Hua-Feng, Zheng Da-Yong, The Roles of circRNAs in Liver Cancer Immunity, Frontiers in Oncology, 10, 2021. Crossref
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Li Zhaodong, Yu Bingxin, Qi Fangyuan, Li Fan, KIF11 Serves as an Independent Prognostic Factor and Therapeutic Target for Patients With Lung Adenocarcinoma, Frontiers in Oncology, 11, 2021. Crossref
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Fuertes Mercedes Beatriz, Domaica Carolina Inés, Zwirner Norberto Walter, Leveraging NKG2D Ligands in Immuno-Oncology, Frontiers in Immunology, 12, 2021. Crossref
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Balta Emre, Wabnitz Guido H., Samstag Yvonne, Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors, International Journal of Molecular Sciences, 22, 11, 2021. Crossref
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Abakushina Elena V., Popova Liubov I., Zamyatnin Andrey A., Werner Jens, Mikhailovsky Nikolay V., Bazhin Alexandr V., The Advantages and Challenges of Anticancer Dendritic Cell Vaccines and NK Cells in Adoptive Cell Immunotherapy, Vaccines, 9, 11, 2021. Crossref
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Vulpis Elisabetta, Loconte Luisa, Peri Agnese, Molfetta Rosa, Caracciolo Giulio, Masuelli Laura, Tomaipitinca Luana, Peruzzi Giovanna, Petillo Sara, Petrucci Maria Teresa, Fazio Francesca, Simonelli Lucilla, Fionda Cinzia, Soriani Alessandra, Cerboni Cristina, Cippitelli Marco, Paolini Rossella, Bernardini Giovanni, Palmieri Gabriella, Santoni Angela, Zingoni Alessandra, Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle‐associated MICA: Dual role in cancer immunosurveillance, Journal of Extracellular Vesicles, 11, 1, 2022. Crossref
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Biber Guy, Sabag Batel, Raiff Anat, Ben‐Shmuel Aviad, Puthenveetil Abhishek, Benichou Jennifer I C, Jubany Tammir, Levy Moria, Killner Shiran, Barda‐Saad Mira, Modulation of intrinsic inhibitory checkpoints using nano‐carriers to unleash NK cell activity, EMBO Molecular Medicine, 14, 1, 2022. Crossref
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Kosta Andrea, Mekhloufi Abdelilah, Lucantonio Lorenzo, Zingoni Alessandra, Soriani Alessandra, Cippitelli Marco, Gismondi Angela, Fazio Francesca, Petrucci Maria Teresa, Santoni Angela, Stabile Helena, Fionda Cinzia, GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells, Frontiers in Immunology, 13, 2022. Crossref