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Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v21.i1-3.100
9 pages

Therapeutic Potential of Leukemia-Derived Dendritic Cells: Preclinical and Clinical Progress

David F. Claxton
Molecular Hematology and Therapy, Box 81, U.T.M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030
John McMannis
Division of Hematology/Oncology, Milton S. Hershey Medical Center, and Department of Blood and Marrow Transplantation, M. D. Anderson Cancer Center
Richard E. Champlin
Department of Hematology, University of Texas, M.D. Anderson Cancer Center, Houston, TX
Aniruddha Choudhury
Department of Hematology, University of Texas, M.D. Anderson Cancer Center, Houston, TX


Human leukemia-derived dendritic cells show potential as tools for therapy. Leukemic cells of patients with chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), and chronic myelomonocytic leukemia (CMML) will all undergo substantial differentiation toward dendritic cells (DC) and may be used to drive autologous T cells to acquire anti-leukemic cytotoxicity. This article describes the use of these human leukemia-derived dendritic cells for stimulation of allogeneic donor lymphocytes and presents a clinical trial of autologous CML DC-stimulated lymphocytes.

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