Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Critical Reviews™ in Immunology
Fator do impacto: 1.404 FI de cinco anos: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v21.i1-3.50
11 pages

Induction and Direction of Immune Responses by Vaccine Adjuvants

Virgil E. J. C. Schijns
Immune Intervention, Cell Biology & Immunology group, Wageningen University, Wageningen, the Netherlands; Epitopoietic Research Corporation, Namur, Belgium

RESUMO

Successful vaccination against infectious or neoplastic disease programs the host's immune system, in a multistep process, to generate an efficient defense and memory response. Conditioning of immune responses to nonreplicating, poorly immunogenic antigens generally requires the help of an adjuvant. The present review attempts to classify vaccine adjuvants functionally, according to recently proposed, mutually exclusive concepts of immunity induction. These include the geographical concept of immune reactivity and the theory of depot effect. Both emphasize the importance of antigen delivery and localization to the lymph node in time after immunization. Other concepts stress the importance of key signals, such as "infectious nonself" or "danger," which influence the activation state of the antigen-presenting cell (APC) and, hence, its capacity to prime naive T cells. The nature of adjuvant-induced immune responses is discussed in relation to each concept.


Articles with similar content:

Viewing Autoimmune Pathogenesis from the Perspective of Antigen Processing and Determinant Hierarchy
Critical Reviews™ in Immunology, Vol.40, 2020, issue 4
Kamal D. Moudgil
CD8 T Cells and Aging
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Rita B. Effros, Phyllis-Jean Linton, Zeling Cai
Elimination of Virus-Specific Cytotoxic T Cells in the Liver
Critical Reviews™ in Immunology, Vol.22, 2002, issue 1
Gunther Dennert
The Contribution of Thymic Stromal Abnormalities to Autoimmune Disease
Critical Reviews™ in Immunology, Vol.31, 2011, issue 3
Melanie N. Hince, Adrienne Calder, Anne L. Fletcher, Ann P. Chidgey, Richard L. Boyd
The Basis of Immunogenicity of Endocrine Allografts
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Ronald G. Gill, Marilyne Coulombe, Mark R. Nicolls