Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Posttranslational Regulation of Cell-Surface Colony-Stimulating Factor-1
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RESUMO
Colony-stimulating factor-1 (CSF-1) plays a central role in the survival, proliferation, differentiation, and function of monocytes and macrophages. CSF-1 is synthesized as both a soluble and a membrane-spanning growth factor. The membrane-spanning isoform is biologically active, but it can also be proteolytically cleaved to generate a soluble growth factor. A recent study revealed that the TNF-α-converting enzyme is involved in this activity, and, moreover, that membrane-spanning CSF-1 undergoes internalization. These findings may have important implications for the posttranslational regulation and the functions of cell-surface CSF-1.
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Horiuchi Keisuke, Morioka Hideo, Takaishi Hironari, Akiyama Haruhiko, Blobel Carl P., Toyama Yoshiaki, Ectodomain Shedding of FLT3 Ligand Is Mediated by TNF-α Converting Enzyme, The Journal of Immunology, 182, 12, 2009. Crossref
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