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Critical Reviews™ in Immunology
Fator do impacto: 1.352 FI de cinco anos: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v18.i6.10
pages 485-501

Developmental Hematopoiesis

S. Morales-Alcelay
Centro Nacional de Biologia Fundamental, Institute de Salud Carlos III, Majadahonda, Madrid, Spain
S. G. Copin
Centro de Biologia Molecular S.O., CSIC-UAM, Campus de Cantoblanco, 28049 Madrid, Spain
J. A. Martinez
Centro Nacional de Biologia Fundamental, Institute de Salud Carlos III, Majadahonda, Madrid, Spain
P. Morales
Centro de Biologia Molecular S.O., CSIC-UAM, Campus de Cantoblanco, 28049 Madrid, Spain
S. Minguet
Centro de Biologia Molecular S.O., CSIC-UAM, Campus de Cantoblanco, 28049 Madrid, Spain
M. L. Gaspar
Centro Nacional de Biologia Fundamental, Institute de Salud Carlos III, Majadahonda, Madrid, Spain
M. A. R. Marcos
Centro de Biologia Molecular S.O., CSIC-UAM, Campus de Cantoblanco, 28049 Madrid, Spain

RESUMO

Hematopoiesis is a developmental process that evolves throughout the lifespan of an individual. Most work in the field has focused on events occurring in the adult bone marrow (BM). In the embryo, blood and endothelial cell generation begins very early after gastrulation, in defined intraembryonic mesodermic sites. Recent multidisciplinary studies, taking advantage of classic embryological and gene targeting technology in various species, have provided a new image of embryofetal lymphohemopoiesis, which includes the suggestion of developmental compartmentalization or waves. The first hematopoietic stem cells (HSC) migrate further and home in an ordered sequence of supporting microenvironments depending on scarcely known molecular requirements. These early hematopoietic progenitors show important differences in their cell biology and differentiation potentialities with respect to those present in adult stages; this fact, together with specific microenvironmental influences, define a process that diverges significantly from that occurring in the BM. Here, we update the latest developments in the field, the new understanding of lymphohemopoiesis in prenatal life, and the novel questions that this emerging paradigm is producing.