Publicou 6 edições por ano
ISSN Imprimir: 1040-8401
ISSN On-line: 2162-6472
Indexed in
Pinning Down Signaling in the Immune System: The Role of the Peptidyl-Prolyl Isomerase Pin1 in Immune Cell Function
RESUMO
The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so differentially from the related PPIases, cyclophilinA and FKBP. This review describes how Pin1 modulates cytokine expression by activated T cells and eosinophils and participates in T-cell and eosinophil apoptotic decisions both in vitro and in vivo. We highlight several possible immunologic diseases, including asthma, as well as organ transplant rejection, where anti-Pin1 therapeutics maybe of value.
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Thapar Roopa, Denmon Andria P., Signaling pathways that control mRNA turnover, Cellular Signalling, 25, 8, 2013. Crossref
-
Zucchelli Chiara, Tamburri Simone, Quilici Giacomo, Palagano Eleonora, Berardi Andrea, Saare Mario, Peterson Pärt, Bachi Angela, Musco Giovanna, Structure of human S p140 PHD finger: an atypical fold interacting with P in1 , The FEBS Journal, 281, 1, 2014. Crossref
-
Huang Guo-Liang, Qiu Jin-Hua, Li Bin-Bin, Wu Jing-Jing, Lu Yan, Liu Xing-Yan, He Zhiwei, Prolyl Isomerase Pin1 Regulated Signaling Pathway Revealed by Pin1 +/+ and Pin1 −/− Mouse Embryonic Fibroblast Cells, Pathology & Oncology Research, 19, 4, 2013. Crossref
-
Polonio-Vallon Tilman, Krüger Daniel, Hofmann Thomas G., ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair, Frontiers in Oncology, 4, 2014. Crossref
-
Guo Chuangxing, Hou Xinjun, Dong Liming, Marakovits Joseph, Greasley Samantha, Dagostino Eleanor, Ferre RoseAnn, Catherine Johnson M., Humphries Paul S., Li Haitao, Paderes Genevieve D., Piraino Joseph, Kraynov Eugenia, Murray Brion W., Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket, Bioorganic & Medicinal Chemistry Letters, 24, 17, 2014. Crossref
-
Hanes Steven D., The Ess1 prolyl isomerase: Traffic cop of the RNA polymerase II transcription cycle, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1839, 4, 2014. Crossref
-
Shen Zhong-Jian, Malter James S., Determinants of eosinophil survival and apoptotic cell death, Apoptosis, 20, 2, 2015. Crossref
-
Isakov Noah, A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling, Trends in Immunology, 29, 8, 2008. Crossref
-
Liou Yih-Cherng, Zhou Xiao Zhen, Lu Kun Ping, Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins, Trends in Biochemical Sciences, 36, 10, 2011. Crossref
-
Dong Liming, Marakovits Joseph, Hou Xinjun, Guo Chuangxing, Greasley Samantha, Dagostino Eleanor, Ferre RoseAnn, Johnson M. Catherine, Kraynov Eugenia, Thomson James, Pathak Ved, Murray Brion W., Structure-based design of novel human Pin1 inhibitors (II), Bioorganic & Medicinal Chemistry Letters, 20, 7, 2010. Crossref
-
Thapar Roopa, Roles of Prolyl Isomerases in RNA-Mediated Gene Expression, Biomolecules, 5, 2, 2015. Crossref
-
Shen Zhong-Jian, Malter James, Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1, Biomolecules, 5, 2, 2015. Crossref
-
Wei Shuo, Yoshida Nobuya, Finn Greg, Kozono Shingo, Nechama Morris, Kyttaris Vasileios C., Zhen Zhou Xiao, Tsokos George C., Ping Lu Kun, Pin1-Targeted Therapy for Systemic Lupus Erythematosus, Arthritis & Rheumatology, 68, 10, 2016. Crossref
-
Han Younho, Lee Sung Ho, Bahn Minjin, Yeo Chang-Yeol, Lee Kwang Youl, Pin1 enhances adipocyte differentiation by positively regulating the transcriptional activity of PPARγ, Molecular and Cellular Endocrinology, 436, 2016. Crossref
-
Krishnan Nithya, Titus Mark A., Thapar Roopa, Mata Juan, The Prolyl Isomerase Pin1 Regulates mRNA Levels of Genes with Short Half-Lives by Targeting Specific RNA Binding Proteins, PLoS ONE, 9, 1, 2014. Crossref
-
Chang Jean-Yun, He Ruei-Yu, Lin Hsin-Ping, Hsu Li-Jin, Lai Feng-Jie, Hong Qunying, Chen Shean-Jen, Chang Nan-Shan, Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase, Experimental Biology and Medicine, 235, 7, 2010. Crossref
-
Esnault Stephane, Shen Zhong-Jian, Malter James S., Protein Translation and Signaling in Human Eosinophils, Frontiers in Medicine, 4, 2017. Crossref
-
Onica Dana, Litchfield David W., Pin1, in Encyclopedia of Signaling Molecules, 2017. Crossref
-
Onica Dana, Litchfield David W., Pin1, in Encyclopedia of Signaling Molecules, 2018. Crossref
-
Gaikwad Sujay, Pawar Yogita, Banerjee Sharmila, Kulkarni Savita, Potential immunomodulatory effect of allelochemical juglone in mice vaccinated with BCG, Toxicon, 157, 2019. Crossref
-
Nechama Morris, Kwon Jeahoo, Wei Shuo, Kyi Adrian Tun, Welner Robert S., Ben-Dov Iddo Z., Arredouani Mohamed S., Asara John M., Chen Chun-Hau, Tsai Cheng-Yu, Nelson Kyle F., Kobayashi Koichi S, Israel Elliot, Zhou Xiao Zhen, Nicholson Linda K., Lu Kun Ping, The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation, Nature Communications, 9, 1, 2018. Crossref
-
Lee Yew Mun, Liou Yih-Cherng, Gears-In-Motion: The Interplay of WW and PPIase Domains in Pin1, Frontiers in Oncology, 8, 2018. Crossref
-
Matena Anja, Rehic Edisa, Hönig Dana, Kamba Bianca, Bayer Peter, Structure and function of the human parvulins Pin1 and Par14/17, Biological Chemistry, 399, 2, 2018. Crossref
-
Huang Min, Li Aihua, Zhao Feng, Xie Xiaorui, Li Kun, Jing Yongkui, Liu Dan, Zhao Linxiang, Design, synthesis and biological evaluation of ring A modified 11-keto-boswellic acid derivatives as Pin1 inhibitors with remarkable anti-prostate cancer activity, Bioorganic & Medicinal Chemistry Letters, 28, 19, 2018. Crossref
-
Schiene-Fischer Cordelia, Aumüller Tobias, Fischer Gunter, Peptide Bond cis/trans Isomerases: A Biocatalysis Perspective of Conformational Dynamics in Proteins, in Molecular Chaperones, 328, 2011. Crossref
-
Schiene‐Fischer Cordelia, Peptidyl Prolyl cis/trans Isomerases , in eLS, 2015. Crossref
-
Xu Ning, Tochio Naoya, Wang Jing, Tamari Yu, Uewaki Jun-ichi, Utsunomiya-Tate Naoko, Igarashi Kazuhiko, Shiraki Takuma, Kobayashi Naohiro, Tate Shin-ichi, The C113D Mutation in Human Pin1 Causes Allosteric Structural Changes in the Phosphate Binding Pocket of the PPIase Domain through the Tug of War in the Dual-Histidine Motif, Biochemistry, 53, 34, 2014. Crossref
-
Chuang Hsiang-Hao, Zhen Yen-Yi, Tsai Yu-Chen, Chuang Cheng-Hao, Huang Ming-Shyan, Hsiao Michael, Yang Chih-Jen, Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy, Biomedicines, 9, 4, 2021. Crossref
-
Reese Shannon, Vidyasagar Aparna, Jacobson Lynn, Acun Zeki, Esnault Stephane, Hullett Debra, Malter James S, Djamali Arjang, The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model, Fibrogenesis & Tissue Repair, 3, 1, 2010. Crossref
-
Cengiz Mustafa, Ozenirler Seren, Yücel Aysegul Atak, Yılmaz Guldal, Can Serum Pin1 Level Be Regarded as an Indicative Marker of Nonalcoholic Steatohepatitis and Fibrotic Stages?, Digestion, 90, 1, 2014. Crossref
-
Nishi Mayuko, Akutsu Hidenori, Masui Shinji, Kondo Asami, Nagashima Yoji, Kimura Hirokazu, Perrem Kilian, Shigeri Yasushi, Toyoda Masashi, Okayama Akiko, Hirano Hisashi, Umezawa Akihiro, Yamamoto Naoki, Lee Sam W., Ryo Akihide, A Distinct Role for Pin1 in the Induction and Maintenance of Pluripotency, Journal of Biological Chemistry, 286, 13, 2011. Crossref
-
Ghosh Anamitra, Saminathan Hariharan, Kanthasamy Arthi, Anantharam Vellareddy, Jin Huajun, Sondarva Gautam, Harischandra Dilshan S., Qian Ziqing, Rana Ajay, Kanthasamy Anumantha G., The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons, Journal of Biological Chemistry, 288, 30, 2013. Crossref
-
Shen Zhong-Jian, Hu Jie, Kashi Venkatesh P., Kelly Elizabeth A., Denlinger Loren C., Lutchman Kevan, McDonald Jeffrey G., Jarjour Nizar N., Malter James S., Epstein-Barr Virus–induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways, American Journal of Respiratory and Critical Care Medicine, 195, 12, 2017. Crossref
-
Salter Brittany, Sehmi Roma, Epstein-Barr Virus–induced Gene 2 and Leukocyte Airway Recruitment in Response to Allergen Challenge, American Journal of Respiratory and Critical Care Medicine, 195, 12, 2017. Crossref
-
Hassan Alia, Pollak Yael E., Kilav-Levin Rachel, Silver Justin, London Nir, Nechama Morris, Ben-Dov Iddo Z., Naveh-Many Tally, Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins, Leading to Secondary Hyperparathyroidism, Journal of the American Society of Nephrology, 33, 9, 2022. Crossref
-
Cincotta Anthony H., Cersosimo Eugenio, Alatrach Mariam, Ezrokhi Michael, Agyin Christina, Adams John, Chilton Robert, Triplitt Curtis, Chamarthi Bindu, Cominos Nicholas, DeFronzo Ralph A., Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Subjects, International Journal of Molecular Sciences, 23, 16, 2022. Crossref
-
Kanna Machi, Nakatsu Yusuke, Yamamotoya Takeshi, Encinas Jeffrey, Ito Hisanaka, Okabe Takayoshi, Asano Tomoichiro, Sakaguchi Takemasa, Roles of peptidyl prolyl isomerase Pin1 in viral propagation, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref