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Critical Reviews™ in Immunology

Publicou 6 edições por ano

ISSN Imprimir: 1040-8401

ISSN On-line: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Recombination in the Human IGK Locus

Volume 26, Edição 1, 2006, pp. 23-42
DOI: 10.1615/CritRevImmunol.v26.i1.20
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RESUMO

The human IGK locus is probably the most complex of all antigen-receptor loci because of the presence of many elements that can be involved in V(D)J recombination. Next to classical Vκ-Jκ recombinations and deletional recombinations involving Kde (intron-Kde, Vκ-Kde), JκRSS-intronRSS signal joints and Vκ-intronRSS and JκRSS-Kde pseudohybrid joints are observed in human B-cell malignancies and also in normal human B cells. These recombinations occur in an ordered and tightly regulated way. Although DNA (de)methylation, histone (de)acetylation, and nuclear positioning all play a role in this regulation, much is still to be learned about the exact factors involved. One of these factors seems to be E2A that is known to be important in B-cell development and has a direct role in the induction of human endogenous IGK recombination. Contrary to the human IGH locus, aberrant recombinations resulting in chromosomal translocations are not very frequent in the human IGK locus. Despite this, IGK recombinations have diagnostic and clinical implications, being important PCR targets for clonality and MRD studies.

CITADO POR
  1. Martínez-Sánchez Pilar, Montejano Laura, Sarasquete Maria Eugenia, García-Sanz Ramón, Fernández-Redondo Elena, Ayala Rosa, Montalbán María Angeles, Martínez Rafael, García Laraña José, Alegre Adrian, Hernández Belen, Lahuerta Juan José, Martínez-López Joaquín, Evaluation of minimal residual disease in multiple myeloma patients by fluorescent-polymerase chain reaction: the prognostic impact of achieving molecular response, British Journal of Haematology, 142, 5, 2008. Crossref

  2. Langerak Anton W, Groenen Patricia JTA, JM van Krieken J Han, van Dongen Jacques JM, Immunoglobulin/T-cell receptor clonality diagnostics, Expert Opinion on Medical Diagnostics, 1, 4, 2007. Crossref

  3. González David, van der Burg Mirjam, García-Sanz Ramón, Fenton James A., Langerak Anton W., González Marcos, van Dongen Jacques J. M., San Miguel Jesus F., Morgan Gareth J., Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma, Blood, 110, 9, 2007. Crossref

  4. Payne Karen, Wright Penny, Grant John W., Huang Yuanxue, Hamoudi Rifat, Bacon Chris M., Du Ming-Qing, Liu Hongxiang, BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma, British Journal of Haematology, 155, 1, 2011. Crossref

  5. Smilevska Tatjana, Tsakou Eugenia, Hadzidimitriou Anastasia, Bikos Vasilis, Stavroyianni Niki, Laoutaris Nikolaos, Fassas Αthanasios, Αnagnostopoulos Achilles, Papadaki Theodora, Belessi Chrysoula, Stamatopoulos Kostas, Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma, Blood Cells, Molecules, and Diseases, 41, 2, 2008. Crossref

  6. Langerak Anton W., van Dongen Jacques J. M., Multiple clonal Ig/TCR products: implications for interpretation of clonality findings, Journal of Hematopathology, 5, 1-2, 2012. Crossref

  7. Hung Sheng-Jou, Chen Yi-Lin, Chu Chia-Hung, Lee Chuan-Chun, Chen Wan-Li, Lin Ya-Lan, Lin Ming-Ching, Ho Chung-Liang, Liu Tsunglin, TRIg: a robust alignment pipeline for non-regular T-cell receptor and immunoglobulin sequences, BMC Bioinformatics, 17, 1, 2016. Crossref

  8. Stevens Sean, Genomic Organization of Murine and Human Immunoglobulin Light Chain Loci, in Encyclopedia of Immunobiology, 2016. Crossref

  9. Zweidler-McKay Patrick A., Borowitz Michael J., Minimal Residual Disease in Acute Lymphoblastic Leukemia, in Adult Acute Lymphocytic Leukemia, 2011. Crossref

  10. van Dongen Jacques J. M., Langerak Anton W., Szczepański Tomasz, Immunoglobulin and T‐Cell Receptor Gene Rearrangement Analysis for Diagnosis of Hematologic Malignancies, in Laboratory Hematology Practice, 2012. Crossref

  11. Hamadou Walid-Sabri, Besbes Sawsen, Bouali Nouha, Mani Rahma, Hafsi Sameh, Khechine Amel, Alaya Nesrine, Gargouri Ali, Youssef Yosra Ben, Khelif Abderrahim, Soua Zohra, Molecular characterization of a Tunisian B-lineage leukemia using Kde gene rearrangements , Journal of Cancer Prevention & Current Research, 13, 1, 2022. Crossref

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