Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Journal of Environmental Pathology, Toxicology and Oncology
Fator do impacto: 1.241 FI de cinco anos: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2013006476
pages 53-58

Cardiotoxicity and Apoptotic Activity in Subacute Endosulfan Toxicity and the Protective Effect of Vitamin C in Rabbits: A Pathological Study

Ozlem Ozmen
Faculty of Veterinary Medicine, Department of Pathology, University of Mehmet Akif Ersoy, Istiklal Yerleskesi, Burdur, Turkey


Cardiovascular disease is one of the most significant causes of mortality in humans and animals, and its etiology is usually unknown. The aim of this study was to investigate the cardiac pathology of endosulfan toxicity and the protective effect of vitamin C in rabbits. Twenty-four rabbits were divided into 4 groups: (1) the END group was given a daily sublethal dose of endosulfan in corn oil by oral gavage for 6 weeks; (2) the END + C group received the endosulfan as well as vitamin C over the same 6-week period; (3) the OIL + C group received corn oil daily and vitamin C every other day; and (4) the OIL group received only corn oil daily. We observed microscopic hemorrhages, single-cell necrosis, inflammatory reactions, and fibrotic changes in the myocardium in the END group. Small hemorrhages and single-cell necrosis also were seen in some hearts in the END + C group, but no inflammation was observed. Caspase-3 immunoreactivity was more significant in myocardial cells in the END group compared with the others. A protective effect of vitamin C on lesions was observed in the END + C group. These results showed that endosulfan resulted in toxic changes in the hearts of rabbits, but this toxicity could be decreased with vitamin C treatment.

Articles with similar content:

Effect of Germanium Citrate on Immunophysiological Activity of the Rats' Organism
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 1
Rostyslav S. Fedoruk, Olga P. Dolaychuk, Maryana I. Khrabko
Changes in the Brain Testosterone Metabolism and Sexual Behavior of Male Rats Prenatally Exposed to Methyldopa and Stress
International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 3
Nadiya D. Nosenko, Anna A. Limareva, Larisa V. Tarasenko, Alexander G. Reznikov
Aqueous Extract of Pecan Nut Shell (Carya illinoensis [Wangenh.] K. Koch) Exerts Protection Against Oxidative Damage Induced by Cyclophosphamide in Rat Testis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 4
Veronica T. Dias, Valdemiro A. da Silva Junior, M.E. Burger, Geisa S. Dolci, Katiane Roversi, Camila S. Pase, Luiz André de Lima, Caren T. D. Antoniazzi, Leandro M. de Carvalho, Fernanda Lima, Hecson J. Segat, Patricia Reckziegel, Raquel C. S. Barcelos, N. Boufleur, Dalila Benvegnu, Fabiola Trevizol
D-Pinitol Protects Against Carbon Tetrachloride−Induced Hepatotoxicity in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 4
Peramaiyan Rajendran, Maruthaiveeran Periyasamy Balasubramanian, Natarajan Nandakumar , Boobathy Lokeshkumar, Thamaraiselvan Rengarajan
The Molecular Mechanism of EPO Regulates the Angiogenesis after Cerebral Ischemia through AMPK-KLF2 Signaling Pathway
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 2
Yan-Qing Deng, Wen-Xin Jiang, Xiao-Li Li, Zu-Neng Lu, Shou-Qin Shangguan, Guang-Hui Chen, Wen-Qin Zou, Fa-Ming Zhou