Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Prevention and Repair of DNA Damage by Selected Phytochemicals as Measured by Single Cell Gel Electrophoresis
RESUMO
We assessed the ability of some natural products−namely, curcumin, resveratrol, indole-3-carbinol, and ellagic acid−to modify the DNA damaging ability of the alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in cultured Chinese hamster lung fibroblast cells (CH V-79). MNNG produced DNA single strand breaks in a dose- and time-dependent manner, as observed by increase in the tail moments of the comet, when the cells were subjected to alkaline single cell gel electrophoresis. When the cells were treated in the presence of each of the natural compounds, the DNA damage caused by MNNG was considerably reduced. This effect was found to be dose related. Preincubation of cells with each of these compounds individually afforded significant protection to DNA against damage caused by subsequent treatment with MNNG, indicating a true chemopreventive role of these substances. The most remarkable aspect of the present study was that all four compounds helped in the recovery of DNA damage by accelerating DNA repair efficiency in the damaged cells. This was further substantiated by the observation on unscheduled DNA synthesis. Our results suggest that these agents are chemopreventive by virtue of their ability to protect DNA as well as to induce DNA repair.
-
Lu Hsu-Feng, Yang Jai-Sing, Lai Kuang-Chi, Hsu Shu-Chun, Hsueh Shu-Ching, Chen Yuan-Liang, Chiang Jo-Hua, Lu Chi-Cheng, Lo Chyi, Yang Mei-Due, Chung Jing-Gung, Curcumin-Induced DNA Damage and Inhibited DNA Repair Genes Expressions in Mouse–Rat Hybrid Retina Ganglion Cells (N18), Neurochemical Research, 34, 8, 2009. Crossref
-
Rieck Gudrun C., Fiander Alison N., Human papillomavirus, cervical carcinogenesis and chemoprevention with Indole derivates - a review of pathomechanisms, Molecular Nutrition & Food Research, 52, 1, 2008. Crossref
-
Cope R. B., Loehr C., Dashwood R., Kerkvliet N. I., Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol, Photochemical & Photobiological Sciences, 5, 5, 2006. Crossref
-
Ramkumar K.M., Sankar L., Manjula C., Krishnamurthi K., Devi S. Saravana, Chakrabarti T., Kalaiselvi K., Palanivel M., Rajaguru P., Antigenotoxic potential ofGymnema montanumleaves on DNA damage in human peripheral blood lymphocytes and HL-60 cell line, Environmental and Molecular Mutagenesis, 2009. Crossref
-
Jagetia Abhinav, Jagetia Ganesh Chandra, Jha Shalini, Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival, Journal of Applied Toxicology, 27, 2, 2007. Crossref
-
Knasmüller Siegfried, Nersesyan Armen, Mišík Miroslav, Gerner Christopher, Mikulits Wolfgang, Ehrlich Veronika, Hoelzl Christine, Szakmary Akos, Wagner Karl-Heinz, Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview, British Journal of Nutrition, 99, E-S1, 2008. Crossref
-
Zinov’eva V. N., Spasov A. A., Mechanisms of the anticancer effects of plant polyphenols. I. Blockade of initiation of carcinogenesis, Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 5, 2, 2011. Crossref
-
Howells Lynne M., Sale Stewart, Sriramareddy Sathya Neelature, Irving Glen R.B., Jones Donald J.L., Ottley Christopher J., Pearson D. Graham, Mann Christopher D., Manson Margaret M., Berry David P., Gescher Andreas, Steward William P., Brown Karen, Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo, International Journal of Cancer, 129, 2, 2011. Crossref
-
Strati Areti, Papoutsi Zoi, Lianidou Evi, Moutsatsou Paraskevi, Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) α+β+ transcript in estrogen receptor-positive MCF-7 breast cancer cells, Clinical Biochemistry, 42, 13-14, 2009. Crossref
-
Meghana Kanitkar, Sanjeev Galande, Ramesh Bhonde, Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: A prophylactic and protective role, European Journal of Pharmacology, 577, 1-3, 2007. Crossref
-
Berni Andrea, Grossi Maria Rosaria, Pepe Gaetano, Filippi Silvia, Muthukumar Sowndarya, Papeschi Cristiano, Natarajan Adayapalam T., Palitti Fabrizio, Protective effect of ellagic acid (EA) on micronucleus formation induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in mammalian cells, in in vitro assays and in vivo, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 746, 1, 2012. Crossref
-
Jagetia Ganesh Chandra, Venkatesha Venkatasubbaiah A., Mangiferin protects human peripheral blood lymphocytes against γ-radiation–induced DNA strand breaks: a fluorescence analysis of DNA unwinding assay, Nutrition Research, 26, 6, 2006. Crossref
-
Grossi Maria Rosaria, Berni Andrea, Pepe Gaetano, Filippi Silvia, Meschini Roberta, Papeschi Cristiano, Natarajan Adayapalam T., Palitti Fabrizio, Evaluation of the effects of ellagic acid (EA) on 7,12-dimethylbenz(α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo, Toxicology Letters, 224, 2, 2014. Crossref
-
Gatz S. A., Wiesmuller L., Take a break--resveratrol in action on DNA, Carcinogenesis, 29, 2, 2008. Crossref
-
Aiyer Harini, Vadhanam Manicka, Stoyanova Radka, Caprio Gerard, Clapper Margie, Gupta Ramesh, Dietary Berries and Ellagic Acid Prevent Oxidative DNA Damage and Modulate Expression of DNA Repair Genes, International Journal of Molecular Sciences, 9, 3, 2008. Crossref
-
Carneiro Cristiene Costa, da Costa Santos Suzana, de Souza Lino Ruy, Bara Maria Teresa Freitas, Chaibub Beatriz Abdallah, de Melo Reis Paulo Roberto, Chaves Dwight Assis, da Silva Antônio Jorge Ribeiro, Silva Luana Santos, de Melo e Silva Daniela, Chen-Chen Lee, Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St.-Hil., Toxicology and Applied Pharmacology, 310, 2016. Crossref
-
Silva Rangel Moreira, Pereira Luciane Dias, Véras Jefferson Hollanda, Vale Camila Regina do, Chen-Chen Lee, Santos Suzana da Costa, Protective effect and induction of DNA repair by Myrciaria cauliflora seed extract and pedunculagin on cyclophosphamide-induced genotoxicity, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 810, 2016. Crossref
-
Huang Sheng-Teng, Yang Rong-Chi, Wu Hsiao-Ting, Wang Chao-Nin, Pang Jong-Hwei S., Lebedeva Irina V., Zinc-Chelation Contributes to the Anti-Angiogenic Effect of Ellagic Acid on Inhibiting MMP-2 Activity, Cell Migration and Tube Formation, PLoS ONE, 6, 5, 2011. Crossref
-
Dobrzyńska Małgorzata M., Gajowik Aneta, Radzikowska Joanna, The effect ofin vivoresveratrol supplementation in irradiated mice on the induction of micronuclei in peripheral blood and bone marrow reticulocytes, Mutagenesis, 31, 4, 2016. Crossref
-
Aydın S, Bacanlı M, Taner G, Şahin T, Başaran AA, Başaran N, Protective effects of resveratrol on sepsis-induced DNA damage in the lymphocytes of rats, Human & Experimental Toxicology, 32, 10, 2013. Crossref
-
Gatz Susanne Andrea, Keimling Marlen, Baumann Cindy, Dörk Thilo, Debatin Klaus-Michael, Fulda Simone, Wiesmüller Lisa, Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR–p53- and –Nbs1-dependent manner, Carcinogenesis, 29, 3, 2008. Crossref
-
López-Romero David, Izquierdo-Vega Jeannett, Morales-González José, Madrigal-Bujaidar Eduardo, Chamorro-Cevallos Germán, Sánchez-Gutiérrez Manuel, Betanzos-Cabrera Gabriel, Alvarez-Gonzalez Isela, Morales-González Ángel, Madrigal-Santillán Eduardo, Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin, Nutrients, 10, 12, 2018. Crossref
-
Bard Robert L., Bartunek Arthur, Shippen Eugene, Diagnosing, Treating, and Reversing Prostate Cancers with Hormonal and Nutritional Intervention, in Image Guided Prostate Cancer Treatments, 2014. Crossref
-
Patel Rachana, Garg Rachana, Erande Suvarna, Maru Girish B., Chemopreventive Herbal Anti-Oxidants: Current Status and Future Perspectives, Journal of Clinical Biochemistry and Nutrition, 40, 2, 2007. Crossref
-
Zinov"eva V.N., Spasov A.A., Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation, Biomeditsinskaya Khimiya, 58, 2, 2012. Crossref
-
Venkatesan Narayanan, Punithavathi Durairaj, Babu Mary, PROTECTION FROM ACUTE AND CHRONIC LUNG DISEASES BY CURCUMIN, in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, 595, 2007. Crossref
-
Zangui Mahtab, Atkin Stephen L., Majeed Muhammed, Sahebkar Amirhossein, Current evidence and future perspectives for curcumin and its analogues as promising adjuncts to oxaliplatin: state-of-the-art, Pharmacological Research, 141, 2019. Crossref
-
Koklesova Lenka, Liskova Alena, Samec Marek, Qaradakhi Tawar, Zulli Anthony, Smejkal Karel, Kajo Karol, Jakubikova Jana, Behzadi Payam, Pec Martin, Zubor Pavol, Biringer Kamil, Kwon Taeg Kyu, Büsselberg Dietrich, Sarria Gustavo R., Giordano Frank A., Golubnitschaja Olga, Kubatka Peter, Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine, EPMA Journal, 11, 2, 2020. Crossref
-
Papoutsi Zoi, Kassi Eva, Tsiapara Anna, Fokialakis Nikolas, Chrousos George P., Moutsatsou Paraskevi, Evaluation of Estrogenic/Antiestrogenic Activity of Ellagic Acid via the Estrogen Receptor Subtypes ERα and ERβ, Journal of Agricultural and Food Chemistry, 53, 20, 2005. Crossref
-
Mendonça Leonardo Meneghin, dos Santos Graciela Cristina, Antonucci Gilmara Ausech, dos Santos Antonio Cardozo, Bianchi Maria de Lourdes Pires, Antunes Lusânia Maria Greggi, Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 675, 1-2, 2009. Crossref
-
Munari Carla Carolina, Ferreira Natália Helen, Nicolella Heloiza Diniz, de Oliveira Pollyanna Francielli, Miranda Mariza Abreu, Bastos Jairo Kenupp, Tavares Denise Crispim, Effects of Glycoalkaloids from Solanum lycocarpum on Genomic Instability, Revista Brasileira de Farmacognosia, 32, 2, 2022. Crossref
-
Li Juan, Dai Cai-Xia, Sun Hua, Jin Lu, Guo Chong-Yi, Cao Wei, Wu Jie, Tian Hai-Yan, Luo Cheng, Ye Wen-Cai, Jiang Ren-Wang, Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo, Toxicology and Applied Pharmacology, 265, 2, 2012. Crossref
-
Silva Fernandes Amanda, Hollanda Véras Jefferson, Silva Luana Santos, Puga Sara Cristina, Luiz Cardoso Bailão Elisa Flávia, de Oliveira Matheus Gabriel, Cardoso Clever Gomes, Carneiro Cristiene Costa, Costa Santos Suzana Da, Chen-Chen Lee, Pedunculagin isolated from Plinia cauliflora seeds exhibits genotoxic, antigenotoxic and cytotoxic effects in bacteria and human lymphocytes, Journal of Toxicology and Environmental Health, Part A, 85, 9, 2022. Crossref
-
Dobrzyńska Małgorzata M., Gajowik Aneta, Protection and Mitigation by Resveratrol of DNA Damage Induced in Irradiated Human Lymphocytes In Vitro, Radiation Research, 197, 2, 2021. Crossref