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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Prevention and Repair of DNA Damage by Selected Phytochemicals as Measured by Single Cell Gel Electrophoresis

Volume 23, Edição 3, 2004, 12 pages
DOI: 10.1615/JEnvPathToxOncol.v23.i3.50
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RESUMO

We assessed the ability of some natural products−namely, curcumin, resveratrol, indole-3-carbinol, and ellagic acid−to modify the DNA damaging ability of the alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in cultured Chinese hamster lung fibroblast cells (CH V-79). MNNG produced DNA single strand breaks in a dose- and time-dependent manner, as observed by increase in the tail moments of the comet, when the cells were subjected to alkaline single cell gel electrophoresis. When the cells were treated in the presence of each of the natural compounds, the DNA damage caused by MNNG was considerably reduced. This effect was found to be dose related. Preincubation of cells with each of these compounds individually afforded significant protection to DNA against damage caused by subsequent treatment with MNNG, indicating a true chemopreventive role of these substances. The most remarkable aspect of the present study was that all four compounds helped in the recovery of DNA damage by accelerating DNA repair efficiency in the damaged cells. This was further substantiated by the observation on unscheduled DNA synthesis. Our results suggest that these agents are chemopreventive by virtue of their ability to protect DNA as well as to induce DNA repair.

CITADO POR
  1. Lu Hsu-Feng, Yang Jai-Sing, Lai Kuang-Chi, Hsu Shu-Chun, Hsueh Shu-Ching, Chen Yuan-Liang, Chiang Jo-Hua, Lu Chi-Cheng, Lo Chyi, Yang Mei-Due, Chung Jing-Gung, Curcumin-Induced DNA Damage and Inhibited DNA Repair Genes Expressions in Mouse–Rat Hybrid Retina Ganglion Cells (N18), Neurochemical Research, 34, 8, 2009. Crossref

  2. Rieck Gudrun C., Fiander Alison N., Human papillomavirus, cervical carcinogenesis and chemoprevention with Indole derivates - a review of pathomechanisms, Molecular Nutrition & Food Research, 52, 1, 2008. Crossref

  3. Cope R. B., Loehr C., Dashwood R., Kerkvliet N. I., Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol, Photochemical & Photobiological Sciences, 5, 5, 2006. Crossref

  4. Ramkumar K.M., Sankar L., Manjula C., Krishnamurthi K., Devi S. Saravana, Chakrabarti T., Kalaiselvi K., Palanivel M., Rajaguru P., Antigenotoxic potential ofGymnema montanumleaves on DNA damage in human peripheral blood lymphocytes and HL-60 cell line, Environmental and Molecular Mutagenesis, 2009. Crossref

  5. Jagetia Abhinav, Jagetia Ganesh Chandra, Jha Shalini, Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival, Journal of Applied Toxicology, 27, 2, 2007. Crossref

  6. Knasmüller Siegfried, Nersesyan Armen, Mišík Miroslav, Gerner Christopher, Mikulits Wolfgang, Ehrlich Veronika, Hoelzl Christine, Szakmary Akos, Wagner Karl-Heinz, Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview, British Journal of Nutrition, 99, E-S1, 2008. Crossref

  7. Zinov’eva V. N., Spasov A. A., Mechanisms of the anticancer effects of plant polyphenols. I. Blockade of initiation of carcinogenesis, Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 5, 2, 2011. Crossref

  8. Howells Lynne M., Sale Stewart, Sriramareddy Sathya Neelature, Irving Glen R.B., Jones Donald J.L., Ottley Christopher J., Pearson D. Graham, Mann Christopher D., Manson Margaret M., Berry David P., Gescher Andreas, Steward William P., Brown Karen, Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo, International Journal of Cancer, 129, 2, 2011. Crossref

  9. Strati Areti, Papoutsi Zoi, Lianidou Evi, Moutsatsou Paraskevi, Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) α+β+ transcript in estrogen receptor-positive MCF-7 breast cancer cells, Clinical Biochemistry, 42, 13-14, 2009. Crossref

  10. Meghana Kanitkar, Sanjeev Galande, Ramesh Bhonde, Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: A prophylactic and protective role, European Journal of Pharmacology, 577, 1-3, 2007. Crossref

  11. Berni Andrea, Grossi Maria Rosaria, Pepe Gaetano, Filippi Silvia, Muthukumar Sowndarya, Papeschi Cristiano, Natarajan Adayapalam T., Palitti Fabrizio, Protective effect of ellagic acid (EA) on micronucleus formation induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in mammalian cells, in in vitro assays and in vivo, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 746, 1, 2012. Crossref

  12. Jagetia Ganesh Chandra, Venkatesha Venkatasubbaiah A., Mangiferin protects human peripheral blood lymphocytes against γ-radiation–induced DNA strand breaks: a fluorescence analysis of DNA unwinding assay, Nutrition Research, 26, 6, 2006. Crossref

  13. Grossi Maria Rosaria, Berni Andrea, Pepe Gaetano, Filippi Silvia, Meschini Roberta, Papeschi Cristiano, Natarajan Adayapalam T., Palitti Fabrizio, Evaluation of the effects of ellagic acid (EA) on 7,12-dimethylbenz(α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo, Toxicology Letters, 224, 2, 2014. Crossref

  14. Gatz S. A., Wiesmuller L., Take a break--resveratrol in action on DNA, Carcinogenesis, 29, 2, 2008. Crossref

  15. Aiyer Harini, Vadhanam Manicka, Stoyanova Radka, Caprio Gerard, Clapper Margie, Gupta Ramesh, Dietary Berries and Ellagic Acid Prevent Oxidative DNA Damage and Modulate Expression of DNA Repair Genes, International Journal of Molecular Sciences, 9, 3, 2008. Crossref

  16. Carneiro Cristiene Costa, da Costa Santos Suzana, de Souza Lino Ruy, Bara Maria Teresa Freitas, Chaibub Beatriz Abdallah, de Melo Reis Paulo Roberto, Chaves Dwight Assis, da Silva Antônio Jorge Ribeiro, Silva Luana Santos, de Melo e Silva Daniela, Chen-Chen Lee, Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St.-Hil., Toxicology and Applied Pharmacology, 310, 2016. Crossref

  17. Silva Rangel Moreira, Pereira Luciane Dias, Véras Jefferson Hollanda, Vale Camila Regina do, Chen-Chen Lee, Santos Suzana da Costa, Protective effect and induction of DNA repair by Myrciaria cauliflora seed extract and pedunculagin on cyclophosphamide-induced genotoxicity, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 810, 2016. Crossref

  18. Huang Sheng-Teng, Yang Rong-Chi, Wu Hsiao-Ting, Wang Chao-Nin, Pang Jong-Hwei S., Lebedeva Irina V., Zinc-Chelation Contributes to the Anti-Angiogenic Effect of Ellagic Acid on Inhibiting MMP-2 Activity, Cell Migration and Tube Formation, PLoS ONE, 6, 5, 2011. Crossref

  19. Dobrzyńska Małgorzata M., Gajowik Aneta, Radzikowska Joanna, The effect ofin vivoresveratrol supplementation in irradiated mice on the induction of micronuclei in peripheral blood and bone marrow reticulocytes, Mutagenesis, 31, 4, 2016. Crossref

  20. Aydın S, Bacanlı M, Taner G, Şahin T, Başaran AA, Başaran N, Protective effects of resveratrol on sepsis-induced DNA damage in the lymphocytes of rats, Human & Experimental Toxicology, 32, 10, 2013. Crossref

  21. Gatz Susanne Andrea, Keimling Marlen, Baumann Cindy, Dörk Thilo, Debatin Klaus-Michael, Fulda Simone, Wiesmüller Lisa, Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR–p53- and –Nbs1-dependent manner, Carcinogenesis, 29, 3, 2008. Crossref

  22. López-Romero David, Izquierdo-Vega Jeannett, Morales-González José, Madrigal-Bujaidar Eduardo, Chamorro-Cevallos Germán, Sánchez-Gutiérrez Manuel, Betanzos-Cabrera Gabriel, Alvarez-Gonzalez Isela, Morales-González Ángel, Madrigal-Santillán Eduardo, Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin, Nutrients, 10, 12, 2018. Crossref

  23. Bard Robert L., Bartunek Arthur, Shippen Eugene, Diagnosing, Treating, and Reversing Prostate Cancers with Hormonal and Nutritional Intervention, in Image Guided Prostate Cancer Treatments, 2014. Crossref

  24. Patel Rachana, Garg Rachana, Erande Suvarna, Maru Girish B., Chemopreventive Herbal Anti-Oxidants: Current Status and Future Perspectives, Journal of Clinical Biochemistry and Nutrition, 40, 2, 2007. Crossref

  25. Zinov"eva V.N., Spasov A.A., Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation, Biomeditsinskaya Khimiya, 58, 2, 2012. Crossref

  26. Venkatesan Narayanan, Punithavathi Durairaj, Babu Mary, PROTECTION FROM ACUTE AND CHRONIC LUNG DISEASES BY CURCUMIN, in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, 595, 2007. Crossref

  27. Zangui Mahtab, Atkin Stephen L., Majeed Muhammed, Sahebkar Amirhossein, Current evidence and future perspectives for curcumin and its analogues as promising adjuncts to oxaliplatin: state-of-the-art, Pharmacological Research, 141, 2019. Crossref

  28. Koklesova Lenka, Liskova Alena, Samec Marek, Qaradakhi Tawar, Zulli Anthony, Smejkal Karel, Kajo Karol, Jakubikova Jana, Behzadi Payam, Pec Martin, Zubor Pavol, Biringer Kamil, Kwon Taeg Kyu, Büsselberg Dietrich, Sarria Gustavo R., Giordano Frank A., Golubnitschaja Olga, Kubatka Peter, Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine, EPMA Journal, 11, 2, 2020. Crossref

  29. Papoutsi Zoi, Kassi Eva, Tsiapara Anna, Fokialakis Nikolas, Chrousos George P., Moutsatsou Paraskevi, Evaluation of Estrogenic/Antiestrogenic Activity of Ellagic Acid via the Estrogen Receptor Subtypes ERα and ERβ, Journal of Agricultural and Food Chemistry, 53, 20, 2005. Crossref

  30. Mendonça Leonardo Meneghin, dos Santos Graciela Cristina, Antonucci Gilmara Ausech, dos Santos Antonio Cardozo, Bianchi Maria de Lourdes Pires, Antunes Lusânia Maria Greggi, Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 675, 1-2, 2009. Crossref

  31. Munari Carla Carolina, Ferreira Natália Helen, Nicolella Heloiza Diniz, de Oliveira Pollyanna Francielli, Miranda Mariza Abreu, Bastos Jairo Kenupp, Tavares Denise Crispim, Effects of Glycoalkaloids from Solanum lycocarpum on Genomic Instability, Revista Brasileira de Farmacognosia, 32, 2, 2022. Crossref

  32. Li Juan, Dai Cai-Xia, Sun Hua, Jin Lu, Guo Chong-Yi, Cao Wei, Wu Jie, Tian Hai-Yan, Luo Cheng, Ye Wen-Cai, Jiang Ren-Wang, Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo, Toxicology and Applied Pharmacology, 265, 2, 2012. Crossref

  33. Silva Fernandes Amanda, Hollanda Véras Jefferson, Silva Luana Santos, Puga Sara Cristina, Luiz Cardoso Bailão Elisa Flávia, de Oliveira Matheus Gabriel, Cardoso Clever Gomes, Carneiro Cristiene Costa, Costa Santos Suzana Da, Chen-Chen Lee, Pedunculagin isolated from Plinia cauliflora seeds exhibits genotoxic, antigenotoxic and cytotoxic effects in bacteria and human lymphocytes, Journal of Toxicology and Environmental Health, Part A, 85, 9, 2022. Crossref

  34. Dobrzyńska Małgorzata M., Gajowik Aneta, Protection and Mitigation by Resveratrol of DNA Damage Induced in Irradiated Human Lymphocytes In Vitro, Radiation Research, 197, 2, 2021. Crossref

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