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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Cytoskeletal Focal Adhesion Proteins Fascin-1 and Paxillin Are Predictors of Malignant Progression and Poor Prognosis in Human Breast Cancer

Volume 34, Edição 3, 2015, pp. 201-212
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013663
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RESUMO

Breast cancer is a major health problem in both developing and developed countries. The incremental motility of malignant cells is a critical step in their migration, invasion, and metastasis and is regulated by the reorganization of the actin cytoskeleton and regulation of focal adhesion. Fascin-1 and paxillin are essential components of these cellular structures. In cancer, the expression level of fascin-1 and paxillin can vary depending on cell type. However, its precise role in breast cancer of Saudi women has not been evaluated in any published study. We investigated fascin-1 and paxillin expression in breast carcinoma, and we have related these results to the established prognostic factors. We studied 100 breast carcinoma specimens. Immunohistochemical analyses for fascin-1 and paxillin were conducted on paraffin sections of breast tissues using the avidin-biotin peroxidase method. Fascin-1 and paxillin were expressed in 58% and 43% of infiltrating duct carcinoma (IDC) cases. There was a statistically significant correlation between fascin-1 and paxillin expression with each of the following: tumor grade, clinical stage, lymph-node metastasis grade, and HER2 expression. Furthermore, there was a significant correlation between fascin-1 expression with paxillin immunostaining but no such association with PR or ER status. Increased fascin-1 and paxillin expression in IDC cells and their correlation with poor prognostic factors support their strong correlation with tumor progression, invasion, and metastasis in human breast cancer, indicating that these markers can be used as a target for the development of novel therapies.

CITADO POR
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  3. Gonzalez-Reyes Christian, Marcial-Medina Cleofas, Cervantes-Anaya Nancy, Cortes-Reynosa Pedro, Salazar Eduardo Perez, Migration and invasion induced by linoleic acid are mediated through fascin in MDA-MB-231 breast cancer cells, Molecular and Cellular Biochemistry, 443, 1-2, 2018. Crossref

  4. Al-Antary Noor, Farghaly Hanan, Aboulkassim Tahar, Yasmeen Amber, Akil Nizar, Al Moustafa Ala-Eddin, Epstein–Barr virus and its association with Fascin expression in colorectal cancers in the Syrian population: A tissue microarray study, Human Vaccines & Immunotherapeutics, 13, 7, 2017. Crossref

  5. Brooks Johanne, Watson Alastair, Korcsmaros Tamas, Omics Approaches to Identify Potential Biomarkers of Inflammatory Diseases in the Focal Adhesion Complex, Genomics, Proteomics & Bioinformatics, 15, 2, 2017. Crossref

  6. Cheng Yinwei, Xie Jianjun, Zeng Famin, Nie Pingjuan, Wu Bingli, Du Zepeng, Pan Feng, Wu Jianyi, Xie Lei, Zhang Pixian, Xu Xiu-e, Liao Liandi, Xie Yangmin, Shen Jian, Wu Zhiyong, Peng Yuhui, Xu Yiwei, Xie Wenming, Wang Shaohong, Lin Xuanhao, Fu Junhui, Zheng Chunpeng, Tao Lihua, Fang Wangkai, Xu Liyan, Li Enmin, Fascin and esophageal squamous cell carcinoma, Precision Radiation Oncology, 1, 3, 2017. Crossref

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